open access
Intraoperative radiation therapy opportunities for clinical practice normalization: Data recording and innovative development
Affiliations- Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
- School of Medicine Complutense University, Madrid, Spain
- Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain
- Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
open access
Abstract
Background
Intraoperative radiotherapy (IORT) refers to the delivery of a high dose of radiation at the time of surgery.
Aim
To analyze clinical and research-oriented innovative activities developed in a 17-year period using intraoperative electron-radiation therapy (IOeRT) as a component of treatment in a multidisciplinary approach for cancer management.
Materials and methods
From 01/1995 to 03/2012 IOeRT procedures were registered in a specific Hospital-based database. Research and developments in imaging and recording for treatment planning implementation are active since 2006.
Results
1004 patients were treated and 1036 IORT procedures completed. Median age of patients was 61 (range 5 months to 94 years). Gender distribution was male in 54% of cases and female in 46%. Disease status at the time of IORT was 796 (77%) primary and 240 (23%) recurrent. Cancer type distribution included: 62% gastrointestinal, 18% sarcoma, 5% pancreas, 2% paediatric, 3% breast, 77 7% oligotopic recurrences, 2% other. IORT technical characteristics were: Applicator size 5[[ce:hsp sp="0.25"/]]cm 22%, 6[[ce:hsp sp="0.25"/]]cm 21%, 7[[ce:hsp sp="0.25"/]]cm 21%, 8[[ce:hsp sp="0.25"/]]cm 15%, 9[[ce:hsp sp="0.25"/]]cm 6%, 10[[ce:hsp sp="0.25"/]]cm 7% 12[[ce:hsp sp="0.25"/]]cm 5% 15[[ce:hsp sp="0.25"/]]cm 3%. Electron energies: 6[[ce:hsp sp="0.25"/]]MeV 19%, 8[[ce:hsp sp="0.25"/]]MeV 15%, 10[[ce:hsp sp="0.25"/]]MeV 15%, 12[[ce:hsp sp="0.25"/]]MeV 23%, 15[[ce:hsp sp="0.25"/]]MeV 19%, 18[[ce:hsp sp="0.25"/]]MeV 6%, other 3%. Multiple fields: 108 (11%). Dose: 7.5[[ce:hsp sp="0.25"/]]Gy 3%, 10[[ce:hsp sp="0.25"/]]Gy 35%, 12[[ce:hsp sp="0.25"/]]Gy 3%, 12.5[[ce:hsp sp="0.25"/]]Gy 49%, 15[[ce:hsp sp="0.25"/]]Gy 5%, other 5%.
Conclusion
An IORT programme developed in an Academic Hospital based on practice-oriented medical decisions is an attractive interdisciplinary oncology initiative proven to be able to generate an intensive clinical activity for cancer patient quality care and a competitive source of scientific patient-oriented research, development and innovation.
Abstract
Background
Intraoperative radiotherapy (IORT) refers to the delivery of a high dose of radiation at the time of surgery.
Aim
To analyze clinical and research-oriented innovative activities developed in a 17-year period using intraoperative electron-radiation therapy (IOeRT) as a component of treatment in a multidisciplinary approach for cancer management.
Materials and methods
From 01/1995 to 03/2012 IOeRT procedures were registered in a specific Hospital-based database. Research and developments in imaging and recording for treatment planning implementation are active since 2006.
Results
1004 patients were treated and 1036 IORT procedures completed. Median age of patients was 61 (range 5 months to 94 years). Gender distribution was male in 54% of cases and female in 46%. Disease status at the time of IORT was 796 (77%) primary and 240 (23%) recurrent. Cancer type distribution included: 62% gastrointestinal, 18% sarcoma, 5% pancreas, 2% paediatric, 3% breast, 77 7% oligotopic recurrences, 2% other. IORT technical characteristics were: Applicator size 5[[ce:hsp sp="0.25"/]]cm 22%, 6[[ce:hsp sp="0.25"/]]cm 21%, 7[[ce:hsp sp="0.25"/]]cm 21%, 8[[ce:hsp sp="0.25"/]]cm 15%, 9[[ce:hsp sp="0.25"/]]cm 6%, 10[[ce:hsp sp="0.25"/]]cm 7% 12[[ce:hsp sp="0.25"/]]cm 5% 15[[ce:hsp sp="0.25"/]]cm 3%. Electron energies: 6[[ce:hsp sp="0.25"/]]MeV 19%, 8[[ce:hsp sp="0.25"/]]MeV 15%, 10[[ce:hsp sp="0.25"/]]MeV 15%, 12[[ce:hsp sp="0.25"/]]MeV 23%, 15[[ce:hsp sp="0.25"/]]MeV 19%, 18[[ce:hsp sp="0.25"/]]MeV 6%, other 3%. Multiple fields: 108 (11%). Dose: 7.5[[ce:hsp sp="0.25"/]]Gy 3%, 10[[ce:hsp sp="0.25"/]]Gy 35%, 12[[ce:hsp sp="0.25"/]]Gy 3%, 12.5[[ce:hsp sp="0.25"/]]Gy 49%, 15[[ce:hsp sp="0.25"/]]Gy 5%, other 5%.
Conclusion
An IORT programme developed in an Academic Hospital based on practice-oriented medical decisions is an attractive interdisciplinary oncology initiative proven to be able to generate an intensive clinical activity for cancer patient quality care and a competitive source of scientific patient-oriented research, development and innovation.
Keywords
Intraoperative radiation therapy; Database; Research
About this articleTitle
Intraoperative radiation therapy opportunities for clinical practice normalization: Data recording and innovative development
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
246-252
Published online
2014-07-01
Page views
199
Article views/downloads
170
DOI
10.1016/j.rpor.2013.07.010
Bibliographic record
Rep Pract Oncol Radiother 2014;19(4):246-252.
Keywords
Intraoperative radiation therapy
Database
Research
Authors
Felipe A. Calvo
Morena Sallabanda
Claudio V. Sole
Carmen Gonzalez
Laura Alonso Murillo
Javier Martinez-Villanueva
Juan A. Santos
Javier Serrano
Ana Alavrez
Jose Blanco
Ana Calin
Marina Gomez-Espi
Miguel Lozano
Rafael Herranz