open access

Vol 19, No 4 (2014)
Original research articles
Published online: 2014-07-01
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Intraoperative radiation therapy opportunities for clinical practice normalization: Data recording and innovative development

Felipe A. Calvo123, Morena Sallabanda2, Claudio V. Sole123, Carmen Gonzalez24, Laura Alonso Murillo2, Javier Martinez-Villanueva2, Juan A. Santos43, Javier Serrano4, Ana Alavrez4, Jose Blanco4, Ana Calin4, Marina Gomez-Espi4, Miguel Lozano4, Rafael Herranz4
DOI: 10.1016/j.rpor.2013.07.010
·
Rep Pract Oncol Radiother 2014;19(4):246-252.
Affiliations
  1. Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  2. School of Medicine Complutense University, Madrid, Spain
  3. Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  4. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

open access

Vol 19, No 4 (2014)
Original research articles
Published online: 2014-07-01

Abstract

Background

Intraoperative radiotherapy (IORT) refers to the delivery of a high dose of radiation at the time of surgery.

Aim

To analyze clinical and research-oriented innovative activities developed in a 17-year period using intraoperative electron-radiation therapy (IOeRT) as a component of treatment in a multidisciplinary approach for cancer management.

Materials and methods

From 01/1995 to 03/2012 IOeRT procedures were registered in a specific Hospital-based database. Research and developments in imaging and recording for treatment planning implementation are active since 2006.

Results

1004 patients were treated and 1036 IORT procedures completed. Median age of patients was 61 (range 5 months to 94 years). Gender distribution was male in 54% of cases and female in 46%. Disease status at the time of IORT was 796 (77%) primary and 240 (23%) recurrent. Cancer type distribution included: 62% gastrointestinal, 18% sarcoma, 5% pancreas, 2% paediatric, 3% breast, 77 7% oligotopic recurrences, 2% other. IORT technical characteristics were: Applicator size 5[[ce:hsp sp="0.25"/]]cm 22%, 6[[ce:hsp sp="0.25"/]]cm 21%, 7[[ce:hsp sp="0.25"/]]cm 21%, 8[[ce:hsp sp="0.25"/]]cm 15%, 9[[ce:hsp sp="0.25"/]]cm 6%, 10[[ce:hsp sp="0.25"/]]cm 7% 12[[ce:hsp sp="0.25"/]]cm 5% 15[[ce:hsp sp="0.25"/]]cm 3%. Electron energies: 6[[ce:hsp sp="0.25"/]]MeV 19%, 8[[ce:hsp sp="0.25"/]]MeV 15%, 10[[ce:hsp sp="0.25"/]]MeV 15%, 12[[ce:hsp sp="0.25"/]]MeV 23%, 15[[ce:hsp sp="0.25"/]]MeV 19%, 18[[ce:hsp sp="0.25"/]]MeV 6%, other 3%. Multiple fields: 108 (11%). Dose: 7.5[[ce:hsp sp="0.25"/]]Gy 3%, 10[[ce:hsp sp="0.25"/]]Gy 35%, 12[[ce:hsp sp="0.25"/]]Gy 3%, 12.5[[ce:hsp sp="0.25"/]]Gy 49%, 15[[ce:hsp sp="0.25"/]]Gy 5%, other 5%.

Conclusion

An IORT programme developed in an Academic Hospital based on practice-oriented medical decisions is an attractive interdisciplinary oncology initiative proven to be able to generate an intensive clinical activity for cancer patient quality care and a competitive source of scientific patient-oriented research, development and innovation.

Abstract

Background

Intraoperative radiotherapy (IORT) refers to the delivery of a high dose of radiation at the time of surgery.

Aim

To analyze clinical and research-oriented innovative activities developed in a 17-year period using intraoperative electron-radiation therapy (IOeRT) as a component of treatment in a multidisciplinary approach for cancer management.

Materials and methods

From 01/1995 to 03/2012 IOeRT procedures were registered in a specific Hospital-based database. Research and developments in imaging and recording for treatment planning implementation are active since 2006.

Results

1004 patients were treated and 1036 IORT procedures completed. Median age of patients was 61 (range 5 months to 94 years). Gender distribution was male in 54% of cases and female in 46%. Disease status at the time of IORT was 796 (77%) primary and 240 (23%) recurrent. Cancer type distribution included: 62% gastrointestinal, 18% sarcoma, 5% pancreas, 2% paediatric, 3% breast, 77 7% oligotopic recurrences, 2% other. IORT technical characteristics were: Applicator size 5[[ce:hsp sp="0.25"/]]cm 22%, 6[[ce:hsp sp="0.25"/]]cm 21%, 7[[ce:hsp sp="0.25"/]]cm 21%, 8[[ce:hsp sp="0.25"/]]cm 15%, 9[[ce:hsp sp="0.25"/]]cm 6%, 10[[ce:hsp sp="0.25"/]]cm 7% 12[[ce:hsp sp="0.25"/]]cm 5% 15[[ce:hsp sp="0.25"/]]cm 3%. Electron energies: 6[[ce:hsp sp="0.25"/]]MeV 19%, 8[[ce:hsp sp="0.25"/]]MeV 15%, 10[[ce:hsp sp="0.25"/]]MeV 15%, 12[[ce:hsp sp="0.25"/]]MeV 23%, 15[[ce:hsp sp="0.25"/]]MeV 19%, 18[[ce:hsp sp="0.25"/]]MeV 6%, other 3%. Multiple fields: 108 (11%). Dose: 7.5[[ce:hsp sp="0.25"/]]Gy 3%, 10[[ce:hsp sp="0.25"/]]Gy 35%, 12[[ce:hsp sp="0.25"/]]Gy 3%, 12.5[[ce:hsp sp="0.25"/]]Gy 49%, 15[[ce:hsp sp="0.25"/]]Gy 5%, other 5%.

Conclusion

An IORT programme developed in an Academic Hospital based on practice-oriented medical decisions is an attractive interdisciplinary oncology initiative proven to be able to generate an intensive clinical activity for cancer patient quality care and a competitive source of scientific patient-oriented research, development and innovation.

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Keywords

Intraoperative radiation therapy; Database; Research

About this article
Title

Intraoperative radiation therapy opportunities for clinical practice normalization: Data recording and innovative development

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 4 (2014)

Pages

246-252

Published online

2014-07-01

Page views

84

Article views/downloads

74

DOI

10.1016/j.rpor.2013.07.010

Bibliographic record

Rep Pract Oncol Radiother 2014;19(4):246-252.

Keywords

Intraoperative radiation therapy
Database
Research

Authors

Felipe A. Calvo
Morena Sallabanda
Claudio V. Sole
Carmen Gonzalez
Laura Alonso Murillo
Javier Martinez-Villanueva
Juan A. Santos
Javier Serrano
Ana Alavrez
Jose Blanco
Ana Calin
Marina Gomez-Espi
Miguel Lozano
Rafael Herranz

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