open access

Vol 19, No 4 (2014)
Original research articles
Published online: 2014-07-01
Submitted: 2013-03-31
Get Citation

Radio-chemotherapy in anal cancer: Institutional experience at a large radiation oncology center in Chile

Moisés Russo, Valentina Ovalle
DOI: 10.1016/j.rpor.2014.02.001
·
Rep Pract Oncol Radiother 2014;19(4):230-233.

open access

Vol 19, No 4 (2014)
Original research articles
Published online: 2014-07-01
Submitted: 2013-03-31

Abstract

Aim

In this article the aim is to provide a concise narrative review and inform the institutional experience at a referral center in Chile with the use of radio-chemotherapy in anal cancer.

Background

Cancer of the anus and anal canal is mainly a loco-regional disease. For years the standard of care has been concomitant radio-chemotherapy, which permits organ preservation and better local control than alternative surgical procedures.

Materials and methods

A retrospective analysis of 44 patients treated between 2002 and 2010 was performed. Local recurrence, distant recurrence and overall survival were analyzed with the Kaplan–Meier method. Relevant groups where compared with the log-rank test and univariate analysis were done with the Cox proportional hazards model.

Results

Median follow-up of the cohort was 56 months, with a minimum follow-up of at least 24 months. There was a significant difference between clinical stages in disease free survival (log-rank trend p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.001), and a significant difference in overall survival (OS) when comparing clinical stages that were grouped in stage I–IIIa and IIIB (log-rank p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.001). On univariate analysis, age older than 60, having received full treatment and dose above 45[[ce:hsp sp="0.25"/]]Gy were all significantly related to OS (p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.05). An overall survival of 45% and disease free survival of 45% at 5 years were found in our series.

Conclusions

Our findings show that results at the Instituto de Radiomedicina in Chile are comparable to published literature. Dismal results in stage IIIb cases indicate much work remains in therapies to achieve loco-regional control in locally advanced cases.

Abstract

Aim

In this article the aim is to provide a concise narrative review and inform the institutional experience at a referral center in Chile with the use of radio-chemotherapy in anal cancer.

Background

Cancer of the anus and anal canal is mainly a loco-regional disease. For years the standard of care has been concomitant radio-chemotherapy, which permits organ preservation and better local control than alternative surgical procedures.

Materials and methods

A retrospective analysis of 44 patients treated between 2002 and 2010 was performed. Local recurrence, distant recurrence and overall survival were analyzed with the Kaplan–Meier method. Relevant groups where compared with the log-rank test and univariate analysis were done with the Cox proportional hazards model.

Results

Median follow-up of the cohort was 56 months, with a minimum follow-up of at least 24 months. There was a significant difference between clinical stages in disease free survival (log-rank trend p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.001), and a significant difference in overall survival (OS) when comparing clinical stages that were grouped in stage I–IIIa and IIIB (log-rank p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.001). On univariate analysis, age older than 60, having received full treatment and dose above 45[[ce:hsp sp="0.25"/]]Gy were all significantly related to OS (p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.05). An overall survival of 45% and disease free survival of 45% at 5 years were found in our series.

Conclusions

Our findings show that results at the Instituto de Radiomedicina in Chile are comparable to published literature. Dismal results in stage IIIb cases indicate much work remains in therapies to achieve loco-regional control in locally advanced cases.

Get Citation

Keywords

Anal cancer; Chemoradiation; Chile

About this article
Title

Radio-chemotherapy in anal cancer: Institutional experience at a large radiation oncology center in Chile

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 4 (2014)

Pages

230-233

Published online

2014-07-01

DOI

10.1016/j.rpor.2014.02.001

Bibliographic record

Rep Pract Oncol Radiother 2014;19(4):230-233.

Keywords

Anal cancer
Chemoradiation
Chile

Authors

Moisés Russo
Valentina Ovalle

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl