First treatment of mycosis fungoides by total skin electron beam (TSEB) therapy in Greece

Abstract

Background

Mycosis fungoides (MF), the most common subtype of cutaneous T-Cell Lymphoma (CTCL), is a rare chronic skin neoplasia. Total skin electron irradiation has been employed along with a variety of other topical or systemic treatments for MF management.

Aim

To report the first case treated by TSEB irradiation protocol in Greece.

Materials and methods

A fractionated 36[[ce:hsp sp="0.25"/]]Gy total skin electron beam (TSEB) therapy was prescribed to a 65-years-old male patient with mycosis fungoides (MF), stage IIB, refractory to several treatments during a 20-year period. Dose uniform delivery was monitored by thermo-luminescence dosimetry.

Results and discussion

The homogeneous skin dose distribution resulted in a complete clinical response. Limited, irradiation-oriented, side effects appeared.

Conclusions

The first TSEB irradiation prescription in Greek medical chronicles was proved effective in this case of tumor stage MF (T3-IIB), which had been refractory to several single or combination treatments.