open access

Vol 19, No 2 (2014)
Special Issue Papers
Published online: 2014-03-01
Submitted: 2013-05-20
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Literature review of clinical results of total skin electron irradiation (TSEBT) of mycosis fungoides in adults

Fabio Ynoe Moraes, Heloisa de Carvalho, Samir Abdallah Hanna, João Luis Silva, Gustavo Nader Marta
DOI: 10.1016/j.rpor.2013.08.003
·
Rep Pract Oncol Radiother 2014;19(2):92-98.

open access

Vol 19, No 2 (2014)
Special Issue Papers
Published online: 2014-03-01
Submitted: 2013-05-20

Abstract

Background

Mycosis fungoides (MF) is an extranodal, indolent non-Hodgkin lymphoma of T cell origin. Even with the establishment of MF staging, the initial treatment strategy often remains unclear.

Aim

The aim of this study was to review the clinical results of total skin electron beam therapy (TSEBT) for MF in adults published in English language scientific journals searched in Pubmed/Medline database until December 2012.

Results

MF is very sensitive to radiation therapy (RT) delivered either by photons or by electrons. In limited patches and/or plaques local electron beam irradiation results in good outcomes besides the fact of not being superior to other modalities. For extensive patches and/or plaques data suggest that TSEBT shows superior response rates. The cutaneous disease presentation is favorably managed with radiotherapy due to its ability to treat the full thickness of deeply infiltrated skin. For generalized erythroderma presentation, TSEBT seems to be an appropriate initial therapy. For advanced disease, palliation, or recurrence after the first radiotherapy treatment course, TSEBT may still be beneficial, with acceptable toxicity. Recommended dose is 30–36[[ce:hsp sp="0.25"/]]Gy delivered in 6–10 weeks.

Conclusion

TSEBT can be used to treat any stage of MF. It also presents good tumor response with symptoms of relief and a palliative effect on MF, either after previous irradiation or failure of other treatment strategies.

Abstract

Background

Mycosis fungoides (MF) is an extranodal, indolent non-Hodgkin lymphoma of T cell origin. Even with the establishment of MF staging, the initial treatment strategy often remains unclear.

Aim

The aim of this study was to review the clinical results of total skin electron beam therapy (TSEBT) for MF in adults published in English language scientific journals searched in Pubmed/Medline database until December 2012.

Results

MF is very sensitive to radiation therapy (RT) delivered either by photons or by electrons. In limited patches and/or plaques local electron beam irradiation results in good outcomes besides the fact of not being superior to other modalities. For extensive patches and/or plaques data suggest that TSEBT shows superior response rates. The cutaneous disease presentation is favorably managed with radiotherapy due to its ability to treat the full thickness of deeply infiltrated skin. For generalized erythroderma presentation, TSEBT seems to be an appropriate initial therapy. For advanced disease, palliation, or recurrence after the first radiotherapy treatment course, TSEBT may still be beneficial, with acceptable toxicity. Recommended dose is 30–36[[ce:hsp sp="0.25"/]]Gy delivered in 6–10 weeks.

Conclusion

TSEBT can be used to treat any stage of MF. It also presents good tumor response with symptoms of relief and a palliative effect on MF, either after previous irradiation or failure of other treatment strategies.

Get Citation

Keywords

Mycosis fungoides; Radiotherapy; Total skin irradiation; Electron beam therapy

About this article
Title

Literature review of clinical results of total skin electron irradiation (TSEBT) of mycosis fungoides in adults

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 2 (2014)

Pages

92-98

Published online

2014-03-01

DOI

10.1016/j.rpor.2013.08.003

Bibliographic record

Rep Pract Oncol Radiother 2014;19(2):92-98.

Keywords

Mycosis fungoides
Radiotherapy
Total skin irradiation
Electron beam therapy

Authors

Fabio Ynoe Moraes
Heloisa de Carvalho
Samir Abdallah Hanna
João Luis Silva
Gustavo Nader Marta

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