open access

Vol 19, No 2 (2014)
Special Issue Papers
Published online: 2014-03-01
Submitted: 2013-07-16
Get Citation

Diagnostics in mycosis fungoides and Sezary syndrome

Karolina Olek-Hrab, Wojciech Silny
DOI: 10.1016/j.rpor.2013.11.001
·
Rep Pract Oncol Radiother 2014;19(2):72-76.

open access

Vol 19, No 2 (2014)
Special Issue Papers
Published online: 2014-03-01
Submitted: 2013-07-16

Abstract

Aim

The aim of this paper was to present diagnostic methods helping in the recognition of mycosis fungoides (MF) and Sezary syndrome (SS).

Background

Mycosis fungoides is the most common form of primary cutaneous T-cell lymphomas. It is characterized by a distinctive long-term course and malignant T-cell proliferation. MF diagnosis is not easy, mainly due to the atypical clinical presentation of the disease at an early stage.

Materials and methods

Low specific changes, which can be observed at the histopathological examination. Initially, the skin lesions may resemble psoriasis, atopic dermatitis or chronic eczema. Patients are qualified according to the available, and generally accepted WHO-EORTC classification, based on a combination of clinical and histopathological markers. From a clinical point of view, it is also important to carry out the qualification according to the TNMB assessment, which allows to specify the stage of the disease, and is helpful in the monitoring of the course of disease and therapeutic effects.

Results

In this paper we try to present currently available diagnostic methods.

Conclusion

Diagnosis of MF and SS still causes many problems due to less characteristic changes in the early stage of disease and requires wide interdisciplinary knowledge.

Abstract

Aim

The aim of this paper was to present diagnostic methods helping in the recognition of mycosis fungoides (MF) and Sezary syndrome (SS).

Background

Mycosis fungoides is the most common form of primary cutaneous T-cell lymphomas. It is characterized by a distinctive long-term course and malignant T-cell proliferation. MF diagnosis is not easy, mainly due to the atypical clinical presentation of the disease at an early stage.

Materials and methods

Low specific changes, which can be observed at the histopathological examination. Initially, the skin lesions may resemble psoriasis, atopic dermatitis or chronic eczema. Patients are qualified according to the available, and generally accepted WHO-EORTC classification, based on a combination of clinical and histopathological markers. From a clinical point of view, it is also important to carry out the qualification according to the TNMB assessment, which allows to specify the stage of the disease, and is helpful in the monitoring of the course of disease and therapeutic effects.

Results

In this paper we try to present currently available diagnostic methods.

Conclusion

Diagnosis of MF and SS still causes many problems due to less characteristic changes in the early stage of disease and requires wide interdisciplinary knowledge.

Get Citation

Keywords

CTCL; Mycosis fungoides; Sezary syndrome; Diagnostics

About this article
Title

Diagnostics in mycosis fungoides and Sezary syndrome

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 2 (2014)

Pages

72-76

Published online

2014-03-01

DOI

10.1016/j.rpor.2013.11.001

Bibliographic record

Rep Pract Oncol Radiother 2014;19(2):72-76.

Keywords

CTCL
Mycosis fungoides
Sezary syndrome
Diagnostics

Authors

Karolina Olek-Hrab
Wojciech Silny

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