open access

Vol 19, No 1 (2014)
Original research articles
Published online: 2014-01-01
Submitted: 2013-05-17
Get Citation

Biological effects and equivalent doses in radiotherapy: A software solution

Cyril Voyant, Daniel Julian, Rudy Roustit, Katia Biffi, Céline Lantieri
DOI: 10.1016/j.rpor.2013.08.004
·
Rep Pract Oncol Radiother 2014;19(1):47-55.

open access

Vol 19, No 1 (2014)
Original research articles
Published online: 2014-01-01
Submitted: 2013-05-17

Abstract

Background

The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding delivered doses or any future prescriptions relating to treatment changes.

Aim

We, therefore, propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model).

Materials and methods

The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames.

Results and conclusions

The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to an equivalent dose computed using standard calculators in seven French radiotherapy centers.

Abstract

Background

The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding delivered doses or any future prescriptions relating to treatment changes.

Aim

We, therefore, propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model).

Materials and methods

The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames.

Results and conclusions

The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to an equivalent dose computed using standard calculators in seven French radiotherapy centers.

Get Citation

Keywords

Radiobiology; Fractionation; Time effect; Linear quadratic; Repopulation

About this article
Title

Biological effects and equivalent doses in radiotherapy: A software solution

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 1 (2014)

Pages

47-55

Published online

2014-01-01

DOI

10.1016/j.rpor.2013.08.004

Bibliographic record

Rep Pract Oncol Radiother 2014;19(1):47-55.

Keywords

Radiobiology
Fractionation
Time effect
Linear quadratic
Repopulation

Authors

Cyril Voyant
Daniel Julian
Rudy Roustit
Katia Biffi
Céline Lantieri

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