open access

Vol 18, No 6 (2013)
SpeciaI issue papers
Published online: 2013-11-01
Submitted: 2013-05-03
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The role of intensity modulated radiotherapy in gynecological radiotherapy: Present and future

Ana Fernandez-Ots, Juanita Crook
DOI: 10.1016/j.rpor.2013.08.001
·
Rep Pract Oncol Radiother 2013;18(6):363-370.

open access

Vol 18, No 6 (2013)
SpeciaI issue papers
Published online: 2013-11-01
Submitted: 2013-05-03

Abstract

Aim

This manuscript reviews the English language literature on the use of intensity modulated radiation therapy (IMRT) for gynecologic malignancies, focusing on the treatment cervical cancer.

Background

Radiation therapy plays a key role in both definitive and adjuvant treatment of these patients, although efforts continue to minimize acute and chronic toxicity. IMRT is an attractive option because of the potential to dose escalate to the target while sparing organs at risk.

Methods and Materials

The English language literature was reviewed for relevant studies.

Results

Multiple heterogeneous studies have showed dosimetric and clinical benefits with reduction in acute and late gastrointestinal, genitourinary and hematologic toxicity, especially in the post hysterectomy scenario and for dose escalation to para-aortic nodes. Consensus is evolving regarding necessary margins and target delineation in the context of organ movement and tumor shrinkage during the course of radiotherapy. Protocols with daily soft-tissue visualization are being investigated.

Conclusions

Consistency in approach and reporting are vital in order to acquire the data to justify the considerable increased expense of IMRT.

Abstract

Aim

This manuscript reviews the English language literature on the use of intensity modulated radiation therapy (IMRT) for gynecologic malignancies, focusing on the treatment cervical cancer.

Background

Radiation therapy plays a key role in both definitive and adjuvant treatment of these patients, although efforts continue to minimize acute and chronic toxicity. IMRT is an attractive option because of the potential to dose escalate to the target while sparing organs at risk.

Methods and Materials

The English language literature was reviewed for relevant studies.

Results

Multiple heterogeneous studies have showed dosimetric and clinical benefits with reduction in acute and late gastrointestinal, genitourinary and hematologic toxicity, especially in the post hysterectomy scenario and for dose escalation to para-aortic nodes. Consensus is evolving regarding necessary margins and target delineation in the context of organ movement and tumor shrinkage during the course of radiotherapy. Protocols with daily soft-tissue visualization are being investigated.

Conclusions

Consistency in approach and reporting are vital in order to acquire the data to justify the considerable increased expense of IMRT.

Get Citation

Keywords

Gynecologic malignancy; Radiotherapy; Intensity modulated radiation; Toxicity

About this article
Title

The role of intensity modulated radiotherapy in gynecological radiotherapy: Present and future

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 18, No 6 (2013)

Pages

363-370

Published online

2013-11-01

DOI

10.1016/j.rpor.2013.08.001

Bibliographic record

Rep Pract Oncol Radiother 2013;18(6):363-370.

Keywords

Gynecologic malignancy
Radiotherapy
Intensity modulated radiation
Toxicity

Authors

Ana Fernandez-Ots
Juanita Crook

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