Interleukin-6 (IL-6) and C-reactive protein (CRP) concentration prior to total nephrectomy are prognostic factors in localized renal cell carcinoma (RCC)
Abstract
Background
Radical nephrectomy is the gold standard for treatment of renal cell carcinoma (RCC), but even for localized disease the survival rates are still unsatisfactory. Identification of prognostic factorsl is the basis for future treatment strategies for an individual patient.
Aim
The aim of our study was to assess the usefulness of the concentration of IL-6 and CRP as prognostic factors in patients after nephrectomy due to localized RCC.
Materials and methods
Our prospective study included 89 patients (55 men and 34 women) who had been surgically treated for RCC. The examined group included patients with localized advanced disease (from T1 to T3) with no metastases in lymph nodes (N0), and with no distant metastases (M0). All patients had blood samples drawn three times during the study (one day before surgery, six days after surgery and 6 months after surgery) to evaluate the concentration of CRP and IL-6. In each patient RCC of the kidney was removed during radical nephrectomy. Statistical analysis was conducted using statistica v.7.0.
Results
Statistically significant relationships were found between the concentration of CRP before the operation and OS (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.0001). CRP concentration at baseline was statistically significantly correlated with CSS (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.0004). The level of IL-6 assessed before the surgery was significantly correlated with survival times such as OS (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.0096) and CSS (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.0002). The concentration of IL-6 and CRP measured 6 days after surgery and 6 months after surgery were not statistically significantly correlated with survival times.
Conclusions
Results of our study showed that elevated levels of IL-6 and CRP in peripheral blood before surgery of RCC were correlated with worse OS and CSS.
Keywords: Renal cell carcinomaInterleukin-6C-reactive proteinPrognostic factorsNephrectomy