open access

Vol 18, No 4 (2013)
Case reports
Published online: 2013-07-01
Submitted: 2012-12-05
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A case report of stereotactic radiosurgery in a patient with Ehlers–Danlos syndrome

Aaron D. Falchook, Timothy M. Zagar
DOI: 10.1016/j.rpor.2013.04.027
·
Rep Pract Oncol Radiother 2013;18(4):241-244.

open access

Vol 18, No 4 (2013)
Case reports
Published online: 2013-07-01
Submitted: 2012-12-05

Abstract

In this report, we outline the case of a patient who has Ehlers–Danlos Syndrome (EDS) who received two courses of CyberKnife stereotactic radiosurgery (SRS) for metastatic non-small cell lung cancer. Patients with EDS have increased blood vessel fragility, and therefore are subject to increased risk of bleeding. There are no published data regarding the risks of hemorrhage associated with SRS for intracranial metastases in this patient population. The patient described in this case report had two courses of SRS for two sites of brain metastases. She tolerated treatment well, with no acute toxicity and good local control to date. We have also included a discussion of published literature regarding toxicity of intracranial radiation in patients with EDS.

Abstract

In this report, we outline the case of a patient who has Ehlers–Danlos Syndrome (EDS) who received two courses of CyberKnife stereotactic radiosurgery (SRS) for metastatic non-small cell lung cancer. Patients with EDS have increased blood vessel fragility, and therefore are subject to increased risk of bleeding. There are no published data regarding the risks of hemorrhage associated with SRS for intracranial metastases in this patient population. The patient described in this case report had two courses of SRS for two sites of brain metastases. She tolerated treatment well, with no acute toxicity and good local control to date. We have also included a discussion of published literature regarding toxicity of intracranial radiation in patients with EDS.

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Keywords

Radiosurgery; CyberKnife; Ehlers–Danlos syndrome

About this article
Title

A case report of stereotactic radiosurgery in a patient with Ehlers–Danlos syndrome

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 18, No 4 (2013)

Pages

241-244

Published online

2013-07-01

DOI

10.1016/j.rpor.2013.04.027

Bibliographic record

Rep Pract Oncol Radiother 2013;18(4):241-244.

Keywords

Radiosurgery
CyberKnife
Ehlers–Danlos syndrome

Authors

Aaron D. Falchook
Timothy M. Zagar

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