open access

Vol 18, No 3 (2013)
Original research articles
Published online: 2013-05-01
Submitted: 2012-06-14
Get Citation

Treatment of pure uterine sarcoma at the

Gonçalo Fernandez, Susanna Marín Borràs, Valentín Navarro Pérez, Ferran Guedea
DOI: 10.1016/j.rpor.2012.12.004
·
Rep Pract Oncol Radiother 2013;18(3):153-158.

open access

Vol 18, No 3 (2013)
Original research articles
Published online: 2013-05-01
Submitted: 2012-06-14

Abstract

Aim

The aim of this retrospective study was to investigate the clinical and histopathological characteristics of the disease and treatment outcome of patients with pure uterine sarcomas.

Background

Uterine sarcomas are especially rare tumours, comprising only 3–5% of uterine cancers. They are characterized by histopathological diversity, rapid clinical progression, and poor prognosis. Optimal management consists of complete surgical removal and adjuvant radiotherapy may improve the prognosis.

Materials and methods

All patients with pure uterine sarcoma histology treated at our centre, the Institut Català D’Oncologia in Barcelona Spain, between 2002 and 2010 were reviewed.

Results

Records of 17 patients treated at our hospital over an 8-year period were obtained. Nine patients (53%) had leiomyosarcoma, 7 (41%) had endometrial stromal sarcoma, and 1 patient had unclassified sarcoma. All patients were treated with external beam radiation after surgical excision. Mean age was 62 years (range, 51–69 years). Of the 17 patients, 13 (76%) presented with stage I disease, 2 (12%) were stage II, and 2 (12%) stage III. The overall actuarial 2-year survival estimate was 82.5%. Two patients experienced local relapse. The 2-year local control rate was 90%. A total of 5 patients experienced either local or metastatic relapse. The 2-year progression free survival rate was 58%.

Conclusion

In our experience, combined treatment (surgery and adjuvant radiation therapy) is effective with acceptable side effects. Larger and multicenter studies are needed to assess treatment outcome for pure uterine sarcoma histology.

Abstract

Aim

The aim of this retrospective study was to investigate the clinical and histopathological characteristics of the disease and treatment outcome of patients with pure uterine sarcomas.

Background

Uterine sarcomas are especially rare tumours, comprising only 3–5% of uterine cancers. They are characterized by histopathological diversity, rapid clinical progression, and poor prognosis. Optimal management consists of complete surgical removal and adjuvant radiotherapy may improve the prognosis.

Materials and methods

All patients with pure uterine sarcoma histology treated at our centre, the Institut Català D’Oncologia in Barcelona Spain, between 2002 and 2010 were reviewed.

Results

Records of 17 patients treated at our hospital over an 8-year period were obtained. Nine patients (53%) had leiomyosarcoma, 7 (41%) had endometrial stromal sarcoma, and 1 patient had unclassified sarcoma. All patients were treated with external beam radiation after surgical excision. Mean age was 62 years (range, 51–69 years). Of the 17 patients, 13 (76%) presented with stage I disease, 2 (12%) were stage II, and 2 (12%) stage III. The overall actuarial 2-year survival estimate was 82.5%. Two patients experienced local relapse. The 2-year local control rate was 90%. A total of 5 patients experienced either local or metastatic relapse. The 2-year progression free survival rate was 58%.

Conclusion

In our experience, combined treatment (surgery and adjuvant radiation therapy) is effective with acceptable side effects. Larger and multicenter studies are needed to assess treatment outcome for pure uterine sarcoma histology.

Get Citation

Keywords

Pure uterine sarcoma; Radiotherapy; Gynecology

About this article
Title

Treatment of pure uterine sarcoma at the

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 18, No 3 (2013)

Pages

153-158

Published online

2013-05-01

DOI

10.1016/j.rpor.2012.12.004

Bibliographic record

Rep Pract Oncol Radiother 2013;18(3):153-158.

Keywords

Pure uterine sarcoma
Radiotherapy
Gynecology

Authors

Gonçalo Fernandez
Susanna Marín Borràs
Valentín Navarro Pérez
Ferran Guedea

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