open access

Vol 18, No 3 (2013)
Reviews
Published online: 2013-05-01
Submitted: 2012-10-04
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Whole brain radiotherapy: Consequences for personalized medicine

Tomáš Kazda, Petr Pospíšil, Hana Doleželová, Radim Jančálek, Pavel Šlampa
DOI: 10.1016/j.rpor.2013.03.002
·
Rep Pract Oncol Radiother 2013;18(3):133-138.

open access

Vol 18, No 3 (2013)
Reviews
Published online: 2013-05-01
Submitted: 2012-10-04

Abstract

Several studies focusing on brain irradiation are in progress. Reflecting updates of relevant outcomes in palliative treatment of patients suffering from brain metastases, the primary objective of these studies is the evaluation of neurocognitive function and quality of life. Improvements of technology in radiation oncology allows us to spare the hippocampal region while appropriately irradiating other parts of brain tissue. Irradiation of the hippocampus region is likely to lead to manifestations of adverse events with a subsequent impact on patient's quality of life, which is in fact an improper approach in palliative medicine. Ongoing studies evaluate results of hippocampus avoiding radiotherapy compared to standard whole brain radiotherapy. Incorporation of neurocognitive function assessment may result in the confirmation of superiority of sparing the region of hippocampus and thus change current style of providing brain irradiation.

Abstract

Several studies focusing on brain irradiation are in progress. Reflecting updates of relevant outcomes in palliative treatment of patients suffering from brain metastases, the primary objective of these studies is the evaluation of neurocognitive function and quality of life. Improvements of technology in radiation oncology allows us to spare the hippocampal region while appropriately irradiating other parts of brain tissue. Irradiation of the hippocampus region is likely to lead to manifestations of adverse events with a subsequent impact on patient's quality of life, which is in fact an improper approach in palliative medicine. Ongoing studies evaluate results of hippocampus avoiding radiotherapy compared to standard whole brain radiotherapy. Incorporation of neurocognitive function assessment may result in the confirmation of superiority of sparing the region of hippocampus and thus change current style of providing brain irradiation.

Get Citation

Keywords

Whole brain radiotherapy; Brain metastases; Decision-making; Personalized medicine

About this article
Title

Whole brain radiotherapy: Consequences for personalized medicine

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 18, No 3 (2013)

Pages

133-138

Published online

2013-05-01

DOI

10.1016/j.rpor.2013.03.002

Bibliographic record

Rep Pract Oncol Radiother 2013;18(3):133-138.

Keywords

Whole brain radiotherapy
Brain metastases
Decision-making
Personalized medicine

Authors

Tomáš Kazda
Petr Pospíšil
Hana Doleželová
Radim Jančálek
Pavel Šlampa

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