open access

Vol 17, No 6 (2012)
Original research articles
Published online: 2012-11-01
Submitted: 2011-07-19
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Role of extended histological examination in the assessment of local recurrence of tongue and floor of the mouth cancer

Bartosz Szybiak, Paweł Trzeciak, Wojciech Golusiński
DOI: 10.1016/j.rpor.2012.06.001
·
Rep Pract Oncol Radiother 2012;17(6):319-323.

open access

Vol 17, No 6 (2012)
Original research articles
Published online: 2012-11-01
Submitted: 2011-07-19

Abstract

Aim

The aim is to find out why the rate of recurrence of tongue and floor of the mouth cancer is so high despite radical surgical treatment combined with radiochemotherapy.

Background

Oropharyngeal cancer is the second most common head and neck cancer in Poland. Tongue cancers account for 40% of all oral cavity tumours. A frequent reason for a failure in treatment of tongue and floor of the mouth cancers is local recurrence. Based on that examination, cancer treatment can be precisely planned.

Materials and methods

The study comprised a group of 56 tongue and floor of the mouth cancer patients. 9 patients who showed local recurrence were given an extended histopathological examination. The infiltration of the vessels, nerves and muscles was examined. The examination also checked the largest dimension of the tumour, the greatest depth of invasion from the mucous membrane, invasive front of the cancer, vessel embolisms, intra- and perineural infiltrations in the cancer invasive front. Tumour aggressiveness was assessed according to M. Brandwein-Gensler.

Results

In five patients, primary tumours were found to be histologically aggressive as indicated by the infiltration of the vessels, nerves and muscles. Tumours which penetrate these structures were characterized with peri- and intraneural infiltration and were correlated with the depth of invasion from the mucous membrane, the occurrence of embolisms, and a high risk assessment as proposed by M. Brandwein-Gensler.

Conclusion

The progression of cancer depends strongly on histopathological traits. The incidence of penetration of the vessels, nerves and muscles correlates with aggressiveness of the tumour front.

Abstract

Aim

The aim is to find out why the rate of recurrence of tongue and floor of the mouth cancer is so high despite radical surgical treatment combined with radiochemotherapy.

Background

Oropharyngeal cancer is the second most common head and neck cancer in Poland. Tongue cancers account for 40% of all oral cavity tumours. A frequent reason for a failure in treatment of tongue and floor of the mouth cancers is local recurrence. Based on that examination, cancer treatment can be precisely planned.

Materials and methods

The study comprised a group of 56 tongue and floor of the mouth cancer patients. 9 patients who showed local recurrence were given an extended histopathological examination. The infiltration of the vessels, nerves and muscles was examined. The examination also checked the largest dimension of the tumour, the greatest depth of invasion from the mucous membrane, invasive front of the cancer, vessel embolisms, intra- and perineural infiltrations in the cancer invasive front. Tumour aggressiveness was assessed according to M. Brandwein-Gensler.

Results

In five patients, primary tumours were found to be histologically aggressive as indicated by the infiltration of the vessels, nerves and muscles. Tumours which penetrate these structures were characterized with peri- and intraneural infiltration and were correlated with the depth of invasion from the mucous membrane, the occurrence of embolisms, and a high risk assessment as proposed by M. Brandwein-Gensler.

Conclusion

The progression of cancer depends strongly on histopathological traits. The incidence of penetration of the vessels, nerves and muscles correlates with aggressiveness of the tumour front.

Get Citation

Keywords

Tongue cancer; Recurrence; Histopathological examination

About this article
Title

Role of extended histological examination in the assessment of local recurrence of tongue and floor of the mouth cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 17, No 6 (2012)

Pages

319-323

Published online

2012-11-01

DOI

10.1016/j.rpor.2012.06.001

Bibliographic record

Rep Pract Oncol Radiother 2012;17(6):319-323.

Keywords

Tongue cancer
Recurrence
Histopathological examination

Authors

Bartosz Szybiak
Paweł Trzeciak
Wojciech Golusiński

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