open access

Vol 17, No 5 (2012)
Special Issue Papers
Published online: 2012-09-01
Submitted: 2011-11-19
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Quality of life and radiotherapy in brain metastasis patients

Gonçalo Fernandez, Rute Pocinho, Catarina Travancinha, Eduardo Netto, Margarida Roldão
DOI: 10.1016/j.rpor.2012.08.003
·
Rep Pract Oncol Radiother 2012;17(5):281-287.

open access

Vol 17, No 5 (2012)
Special Issue Papers
Published online: 2012-09-01
Submitted: 2011-11-19

Abstract

Aim

The primary objective of this study was to assess whether there was an improvement in QoL for patients with brain metastases after radiotherapy treatments.

Background

Assessment of quality of life (QoL) in brain metastasis patients has become increasingly recognized as an important outcome.

Materials and methods

Patients treated for brain metastasis in our department during 2010 were included in our prospective study. QoL assessments were conducted at baseline, 1 month, and 3 months after completion of whole-brain radiotherapy (WBRT). Wilcoxon test for multiple comparisons was calculated to detect significant differences in global QoL scores.

Results

Thirty-nine patients with brain metastases completed the EORTC QLQ-C30/BN-20 questionnaire independently. Median age was 59.9 years (from 37 to 81 years). Our results report differences between the baseline and 3 months in worsening of a global health status (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.034) and cognitive function (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.004), as well as drowsiness (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.001), appetite loss (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.031) and hair loss (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.005). There is a tendency for deterioration of physical function (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.004), communication deficit (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.012), and weakness of legs (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.024), between the baseline and 1 month evaluation. There was no difference in a global cognitive status between different evaluations. Median survival time was 3 months (CI 95% 1.85; 4.15).

Conclusions

Our findings indicate a small deterioration for a global QoL status, and large deterioration for cognitive function after radiation treatments, as well as worsening of brain metastasis related symptom items. Further research is necessary to refine treatment selection for patients with brain metastases, since it may at least contribute to the stabilization of their QoL status.

Abstract

Aim

The primary objective of this study was to assess whether there was an improvement in QoL for patients with brain metastases after radiotherapy treatments.

Background

Assessment of quality of life (QoL) in brain metastasis patients has become increasingly recognized as an important outcome.

Materials and methods

Patients treated for brain metastasis in our department during 2010 were included in our prospective study. QoL assessments were conducted at baseline, 1 month, and 3 months after completion of whole-brain radiotherapy (WBRT). Wilcoxon test for multiple comparisons was calculated to detect significant differences in global QoL scores.

Results

Thirty-nine patients with brain metastases completed the EORTC QLQ-C30/BN-20 questionnaire independently. Median age was 59.9 years (from 37 to 81 years). Our results report differences between the baseline and 3 months in worsening of a global health status (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.034) and cognitive function (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.004), as well as drowsiness (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.001), appetite loss (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.031) and hair loss (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.005). There is a tendency for deterioration of physical function (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.004), communication deficit (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.012), and weakness of legs (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.024), between the baseline and 1 month evaluation. There was no difference in a global cognitive status between different evaluations. Median survival time was 3 months (CI 95% 1.85; 4.15).

Conclusions

Our findings indicate a small deterioration for a global QoL status, and large deterioration for cognitive function after radiation treatments, as well as worsening of brain metastasis related symptom items. Further research is necessary to refine treatment selection for patients with brain metastases, since it may at least contribute to the stabilization of their QoL status.

Get Citation

Keywords

Brain metastases; Quality-of-life; Radiotherapy; Whole brain radiotherapy

About this article
Title

Quality of life and radiotherapy in brain metastasis patients

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 17, No 5 (2012)

Pages

281-287

Published online

2012-09-01

DOI

10.1016/j.rpor.2012.08.003

Bibliographic record

Rep Pract Oncol Radiother 2012;17(5):281-287.

Keywords

Brain metastases
Quality-of-life
Radiotherapy
Whole brain radiotherapy

Authors

Gonçalo Fernandez
Rute Pocinho
Catarina Travancinha
Eduardo Netto
Margarida Roldão

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