open access

Vol 17, No 5 (2012)
Special Issue Papers
Published online: 2012-09-01
Submitted: 2011-09-28
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Detection of risk factors that influence weight loss in patients undergoing radiotherapy

Jon Cacicedo, Francisco Casquero, Lorea Martinez-Indart, Olga del Hoyo, Alfonso Gómez Iturriaga, Irma Muruzabal, Claudia Carvajal, Elsira Bóveda, Blanca Ruiz, Armando Loayza, Begoña Usategui, Aurora Lasso, Eduardo Hortelano, Pedro Bilbao
DOI: 10.1016/j.rpor.2012.07.017
·
Rep Pract Oncol Radiother 2012;17(5):269-275.

open access

Vol 17, No 5 (2012)
Special Issue Papers
Published online: 2012-09-01
Submitted: 2011-09-28

Abstract

Aim

To identify risk factors that influence weight loss in patients receiving radiotherapy.

Background

It is a well-known fact that cancer patients can be affected by malnutrition at the onset of the disease and during treatment due to the toxicity. Pretreatment weight loss alone does not predict those who will need nutritional supplementation. Instead, a variety of nutritional and tumor related factors needs to be taken into account.

Material and methods

A retrospective study was conducted on 129 patients with different tumor locations. Weight loss was evaluated during radiotherapy and one month after treatment. The impact of age, ECOG, chemotherapy, pretreatment weight loss, tumor location, previous surgery and TNM were analyzed. We aimed to identify a high-risk group of patients before starting treatment.

Results

The average net weight loss during radiotherapy and one month after treatment for this group of patients was 0.68[[ce:hsp sp="0.25"/]]kg and 1.6[[ce:hsp sp="0.25"/]]kg, respectively. Median weight loss during radiotherapy was 2.6 kg for head and neck (HN) patients and 0.27 [[ce:hsp sp="0.25"/]]kg for other tumor sites (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.028). Median weight loss one month after radiotherapy was 3.7[[ce:hsp sp="0.25"/]]kg for HN patients and 1.1[[ce:hsp sp="0.25"/]]kg for the rest of the patients (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.034). The median weight loss one month after treatment was 3.2 kg for patients receiving chemotherapy and 0.5[[ce:hsp sp="0.25"/]]kg for those patients who did not receive chemotherapy (p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.001). A regression analysis determined that HN tumor location and the use of chemotherapy were independent risk factors.

Conclusions

Nutritional status must be monitored and managed before, during and after treatment. A variety of nutritional and tumor-related factors must be considered. According to our results, head and neck tumors and the use of chemotherapy are the only two factors considered statistically significant. Because patients continue to lose weight after treatment, we recommend close surveillance after radiotherapy.

Abstract

Aim

To identify risk factors that influence weight loss in patients receiving radiotherapy.

Background

It is a well-known fact that cancer patients can be affected by malnutrition at the onset of the disease and during treatment due to the toxicity. Pretreatment weight loss alone does not predict those who will need nutritional supplementation. Instead, a variety of nutritional and tumor related factors needs to be taken into account.

Material and methods

A retrospective study was conducted on 129 patients with different tumor locations. Weight loss was evaluated during radiotherapy and one month after treatment. The impact of age, ECOG, chemotherapy, pretreatment weight loss, tumor location, previous surgery and TNM were analyzed. We aimed to identify a high-risk group of patients before starting treatment.

Results

The average net weight loss during radiotherapy and one month after treatment for this group of patients was 0.68[[ce:hsp sp="0.25"/]]kg and 1.6[[ce:hsp sp="0.25"/]]kg, respectively. Median weight loss during radiotherapy was 2.6 kg for head and neck (HN) patients and 0.27 [[ce:hsp sp="0.25"/]]kg for other tumor sites (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.028). Median weight loss one month after radiotherapy was 3.7[[ce:hsp sp="0.25"/]]kg for HN patients and 1.1[[ce:hsp sp="0.25"/]]kg for the rest of the patients (p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.034). The median weight loss one month after treatment was 3.2 kg for patients receiving chemotherapy and 0.5[[ce:hsp sp="0.25"/]]kg for those patients who did not receive chemotherapy (p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.001). A regression analysis determined that HN tumor location and the use of chemotherapy were independent risk factors.

Conclusions

Nutritional status must be monitored and managed before, during and after treatment. A variety of nutritional and tumor-related factors must be considered. According to our results, head and neck tumors and the use of chemotherapy are the only two factors considered statistically significant. Because patients continue to lose weight after treatment, we recommend close surveillance after radiotherapy.

Get Citation

Keywords

Risk factor; Nutrition; Radiotherapy; Weight loss

About this article
Title

Detection of risk factors that influence weight loss in patients undergoing radiotherapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 17, No 5 (2012)

Pages

269-275

Published online

2012-09-01

DOI

10.1016/j.rpor.2012.07.017

Bibliographic record

Rep Pract Oncol Radiother 2012;17(5):269-275.

Keywords

Risk factor
Nutrition
Radiotherapy
Weight loss

Authors

Jon Cacicedo
Francisco Casquero
Lorea Martinez-Indart
Olga del Hoyo
Alfonso Gómez Iturriaga
Irma Muruzabal
Claudia Carvajal
Elsira Bóveda
Blanca Ruiz
Armando Loayza
Begoña Usategui
Aurora Lasso
Eduardo Hortelano
Pedro Bilbao

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