open access

Vol 17, No 3 (2012)
Case reports
Published online: 2012-05-01
Submitted: 2011-09-11
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HDR-plesiotherapy for the treatment of anogenital extramammary Paget's disease

Soraya Marcos, Angel Montero, Belén Capuz, Javier Martinez-Ollero, Raúl Hernanz, Eva Fernández, Alfredo Polo, Alfredo Ramos
DOI: 10.1016/j.rpor.2012.03.006
·
Rep Pract Oncol Radiother 2012;17(3):163-167.

open access

Vol 17, No 3 (2012)
Case reports
Published online: 2012-05-01
Submitted: 2011-09-11

Abstract

Background

Extramammary Paget disease (EMPD) is a rare condition that most commonly affects the anogenital region in the elderly. It may be associated with an underlying invasive carcinoma. Surgical excision is nowadays considered a standard treatment for extramammary Paget's disease, although this approach might not be suitable for all patients. Good rates of local control and cosmetic outcome have been achieved by using high-dose-rate (HDR) plesiotherapy in the treatment of skin tumors arising in different locations.

Material and methods

We present the results observed in a patient with EMPD treated by HDR plesiotherapy with a custom-made mold up to a final dose of 54[[ce:hsp sp="0.25"/]]Gy in 12 fractions of 450 cGy over 4 weeks.

Results

After a follow-up of 18 months, the patient is alive and without evidence of local or distant relapse. Acute toxicity was acceptable and cosmetic result was considered as excellent.

Conclusion

This technique represents an attractive alternative for those patients who are not candidates for surgical procedures because of unacceptable risk of disfigurements or functional impairment, medical contraindications or patient preference.

Abstract

Background

Extramammary Paget disease (EMPD) is a rare condition that most commonly affects the anogenital region in the elderly. It may be associated with an underlying invasive carcinoma. Surgical excision is nowadays considered a standard treatment for extramammary Paget's disease, although this approach might not be suitable for all patients. Good rates of local control and cosmetic outcome have been achieved by using high-dose-rate (HDR) plesiotherapy in the treatment of skin tumors arising in different locations.

Material and methods

We present the results observed in a patient with EMPD treated by HDR plesiotherapy with a custom-made mold up to a final dose of 54[[ce:hsp sp="0.25"/]]Gy in 12 fractions of 450 cGy over 4 weeks.

Results

After a follow-up of 18 months, the patient is alive and without evidence of local or distant relapse. Acute toxicity was acceptable and cosmetic result was considered as excellent.

Conclusion

This technique represents an attractive alternative for those patients who are not candidates for surgical procedures because of unacceptable risk of disfigurements or functional impairment, medical contraindications or patient preference.

Get Citation

Keywords

Extramammary Paget' s disease; Anogenital region; Superficial brachytherapy; HDR plesiotherapy; Custom-made mold

About this article
Title

HDR-plesiotherapy for the treatment of anogenital extramammary Paget's disease

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 17, No 3 (2012)

Pages

163-167

Published online

2012-05-01

DOI

10.1016/j.rpor.2012.03.006

Bibliographic record

Rep Pract Oncol Radiother 2012;17(3):163-167.

Keywords

Extramammary Paget's disease
Anogenital region
Superficial brachytherapy
HDR plesiotherapy
Custom-made mold

Authors

Soraya Marcos
Angel Montero
Belén Capuz
Javier Martinez-Ollero
Raúl Hernanz
Eva Fernández
Alfredo Polo
Alfredo Ramos

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