open access

Vol 16, No 6 (2011)
Published online: 2011-11-01
Submitted: 2011-04-18
Get Citation

The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy

Arkadiusz Spychała, Dawid Murawa, Konstanty Korski
DOI: 10.1016/j.rpor.2011.08.002
·
Rep Pract Oncol Radiother 2011;16(6):232-236.

open access

Vol 16, No 6 (2011)
Published online: 2011-11-01
Submitted: 2011-04-18

Abstract

Background

In spite of radical gastrectomy with resection of the lymphatic system, where no metastases are found during histopathological examination, about 30% of patients have relapse of the neoplastic process. This situation may be caused by micrometastases or isolated neoplastic cells in the lymphatic system which were not identified during a standard histopathological examination.

Aim

The aim of the study was to evaluate the clinical importance of micrometastases within the lymphatic system in patients with gastric cancer.

Materials and methods

A group of 20 patients treated for gastric cancer were subjected to retrospective analysis. Of all the patients who underwent surgery, a group with tumours classified as T1 or T2 was selected. No metastases within the lymphatic system were found in the standard evaluation – N0 mark. Paraffin-embedded blocks of lymph nodes were cut and new specimens were made, which were then stained again by means of immunohistochemistry. Antibodies against cytokeratin AE1/AE3 were used.

Results

A total of 319 lymph nodes were assessed in 20 patients in an H[[ce:hsp sp="0.25"/]]+[[ce:hsp sp="0.25"/]]E examination. After the immunohistochemical examination, micrometastases within the lymphatic system were found in 4 (20%) patients and isolated neoplastic cells in other 4 (20%) patients.

Conclusion

On the basis of numerous publications and our own material, we think that the presence of micrometastases may be related to a worse prognosis. The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy.

Abstract

Background

In spite of radical gastrectomy with resection of the lymphatic system, where no metastases are found during histopathological examination, about 30% of patients have relapse of the neoplastic process. This situation may be caused by micrometastases or isolated neoplastic cells in the lymphatic system which were not identified during a standard histopathological examination.

Aim

The aim of the study was to evaluate the clinical importance of micrometastases within the lymphatic system in patients with gastric cancer.

Materials and methods

A group of 20 patients treated for gastric cancer were subjected to retrospective analysis. Of all the patients who underwent surgery, a group with tumours classified as T1 or T2 was selected. No metastases within the lymphatic system were found in the standard evaluation – N0 mark. Paraffin-embedded blocks of lymph nodes were cut and new specimens were made, which were then stained again by means of immunohistochemistry. Antibodies against cytokeratin AE1/AE3 were used.

Results

A total of 319 lymph nodes were assessed in 20 patients in an H[[ce:hsp sp="0.25"/]]+[[ce:hsp sp="0.25"/]]E examination. After the immunohistochemical examination, micrometastases within the lymphatic system were found in 4 (20%) patients and isolated neoplastic cells in other 4 (20%) patients.

Conclusion

On the basis of numerous publications and our own material, we think that the presence of micrometastases may be related to a worse prognosis. The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy.

Get Citation

Keywords

Micrometastases; Gastric cancer; Isolated tumour cells

About this article
Title

The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 16, No 6 (2011)

Pages

232-236

Published online

2011-11-01

DOI

10.1016/j.rpor.2011.08.002

Bibliographic record

Rep Pract Oncol Radiother 2011;16(6):232-236.

Keywords

Micrometastases
Gastric cancer
Isolated tumour cells

Authors

Arkadiusz Spychała
Dawid Murawa
Konstanty Korski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl