open access

Vol 16, No 4 (2011)
Special Issue Papers
Published online: 2011-07-01
Submitted: 2011-05-03
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Radiobiology of the acute radiation syndrome

Miquel Macià i Garau, Anna Lucas Calduch, Enric Casanovas López
DOI: 10.1016/j.rpor.2011.06.001
·
Rep Pract Oncol Radiother 2011;16(4):123-130.

open access

Vol 16, No 4 (2011)
Special Issue Papers
Published online: 2011-07-01
Submitted: 2011-05-03

Abstract

Acute radiation syndrome or acute radiation sickness is classically subdivided into three subsyndromes: the hematopoietic, gastrointestinal and neurovascular syndrome but many other tissues can be damaged. The time course and severity of clinical signs and symptoms are a function of the overall body volume irradiated, the inhomogeneity of dose exposure, the particle type, the absorbed dose and the dose rate. Classical pathophysiology explain the failure of each of these organs and the timing of appearance of their signs and symptoms due to radiation-induced cytocidal effects of a great number of parenchymal cells of hierarchically organized tissues. Contemporaneously, many other radiation-induced effects has been described and all of them may lead to tissue injury with their corresponding signs and symptoms that can be expressed after short or long period of time. Radiation-induced multi-organ involvement is thought to be due to radiation-induced systemic inflammatory response mediated by released pro-inflammatory cytokines.

Abstract

Acute radiation syndrome or acute radiation sickness is classically subdivided into three subsyndromes: the hematopoietic, gastrointestinal and neurovascular syndrome but many other tissues can be damaged. The time course and severity of clinical signs and symptoms are a function of the overall body volume irradiated, the inhomogeneity of dose exposure, the particle type, the absorbed dose and the dose rate. Classical pathophysiology explain the failure of each of these organs and the timing of appearance of their signs and symptoms due to radiation-induced cytocidal effects of a great number of parenchymal cells of hierarchically organized tissues. Contemporaneously, many other radiation-induced effects has been described and all of them may lead to tissue injury with their corresponding signs and symptoms that can be expressed after short or long period of time. Radiation-induced multi-organ involvement is thought to be due to radiation-induced systemic inflammatory response mediated by released pro-inflammatory cytokines.

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Keywords

Radiobiology; Acute radiation syndrome; Hematopoietic syndrome; Gastrointestinal syndrome; Neurovascular syndrome; Radiation-induced multi-organ involvement; Radiation-induced multi-organ failure

About this article
Title

Radiobiology of the acute radiation syndrome

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 16, No 4 (2011)

Pages

123-130

Published online

2011-07-01

DOI

10.1016/j.rpor.2011.06.001

Bibliographic record

Rep Pract Oncol Radiother 2011;16(4):123-130.

Keywords

Radiobiology
Acute radiation syndrome
Hematopoietic syndrome
Gastrointestinal syndrome
Neurovascular syndrome
Radiation-induced multi-organ involvement
Radiation-induced multi-organ failure

Authors

Miquel Macià i Garau
Anna Lucas Calduch
Enric Casanovas López

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