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Stevens Johnson Syndrome in a patient undergoing gynaecological brachytherapy: An association or an incident?
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Abstract
Background
Stevens Johnson Syndrome and Erythema Multiforme are hypersensitivity skin reactions generally arising in the context of multiple causes. Radiation therapy is considered to be one of these causes, although most reports are hindered by concomitant medications.
Aim
The aim of this paper was to present a case of Stevens Johnson Syndrome arising in a patient undergoing gynaecological brachytherapy with an unusual presentation.
Case
We describe a case of a 56-year-old woman with endometrial cancer undergoing adjuvant gynaecological radiotherapy. While undergoing a gynaecological brachytherapy boost, she developed bilateral conjunctivitis that progressed to oral mucositis and pruritic erythema with sloughing of the skin on her arms and legs but not the torso or irradiated fields (namely the vaginal mucosa).
Conclusion
This case illustrates the association of RT/SJS; however, it also raises the question of patients undergoing RT being more susceptible to SJS as opposed to a direct cause of the disease.
Abstract
Background
Stevens Johnson Syndrome and Erythema Multiforme are hypersensitivity skin reactions generally arising in the context of multiple causes. Radiation therapy is considered to be one of these causes, although most reports are hindered by concomitant medications.
Aim
The aim of this paper was to present a case of Stevens Johnson Syndrome arising in a patient undergoing gynaecological brachytherapy with an unusual presentation.
Case
We describe a case of a 56-year-old woman with endometrial cancer undergoing adjuvant gynaecological radiotherapy. While undergoing a gynaecological brachytherapy boost, she developed bilateral conjunctivitis that progressed to oral mucositis and pruritic erythema with sloughing of the skin on her arms and legs but not the torso or irradiated fields (namely the vaginal mucosa).
Conclusion
This case illustrates the association of RT/SJS; however, it also raises the question of patients undergoing RT being more susceptible to SJS as opposed to a direct cause of the disease.
Keywords
Stevens Johnson Syndrome; Radiotherapy; Brachytherapy; Erythema Multiforme; Endometrial cancer; Stevens Johnson
About this articleTitle
Stevens Johnson Syndrome in a patient undergoing gynaecological brachytherapy: An association or an incident?
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
115-117
Published online
2011-05-01
DOI
10.1016/j.rpor.2011.02.002
Bibliographic record
Rep Pract Oncol Radiother 2011;16(3):115-117.
Keywords
Stevens Johnson Syndrome
Radiotherapy
Brachytherapy
Erythema Multiforme
Endometrial cancer
Stevens Johnson
Authors
Miguel Reis Ferreira
Ana Amado
Marília Jorge
Isabel Monteiro Grillo