open access

Vol 16, No 3 (2011)
Published online: 2011-05-01
Submitted: 2010-11-10
Get Citation

Sentinel node biopsy in breast cancer using infrared laser system first experience with PDE camera

Karol Polom, Dawid Murawa, Michał Michalak, Paweł Murawa
DOI: 10.1016/j.rpor.2011.02.005
·
Rep Pract Oncol Radiother 2011;16(3):82-86.

open access

Vol 16, No 3 (2011)
Published online: 2011-05-01
Submitted: 2010-11-10

Abstract

Background

Sentinel node biopsy (SNB) is a gold standard in staging of early breast cancer. Nowadays, routine mapping of lymphatic tract is based on two tracers: human albumin with radioactive technetium, with or without blue dye. Recent years have seen a search for new tracers to examine sentinel node as well as lymphatic network. One of them is indocyanine green (ICG) visible in infrared light.

Aim

The aim of this study is to evaluate clinical usage of ICG in comparison with standard tracer, i.e. nanocoll, in SNB of breast cancer patients.

Materials and methods

In the 1st Department of Surgical Oncology and General Surgery, Greater Poland Cancer Centre, Poznań, 13 female breast cancer patients have benn operated since September 2010. All these patients had sentinel node biopsy with nanocoll (human albumin with radioactive technetium), and with indocyanine green. The feasibility of this new method was assessed in comparison with the standard nanocoll.

Results

A lymphatic network between the place of injection of ICG and sentinel node was seen in infrared light. An area where a sentinel node was possibly located was confirmed by gamma probe. Sensitivity of this method was 100%.

Conclusion

SNB using ICG is a new, promising diagnostics technique. This procedure is not without drawbacks; nevertheless it opens new horizons in lymphatic network diagnostics.

Abstract

Background

Sentinel node biopsy (SNB) is a gold standard in staging of early breast cancer. Nowadays, routine mapping of lymphatic tract is based on two tracers: human albumin with radioactive technetium, with or without blue dye. Recent years have seen a search for new tracers to examine sentinel node as well as lymphatic network. One of them is indocyanine green (ICG) visible in infrared light.

Aim

The aim of this study is to evaluate clinical usage of ICG in comparison with standard tracer, i.e. nanocoll, in SNB of breast cancer patients.

Materials and methods

In the 1st Department of Surgical Oncology and General Surgery, Greater Poland Cancer Centre, Poznań, 13 female breast cancer patients have benn operated since September 2010. All these patients had sentinel node biopsy with nanocoll (human albumin with radioactive technetium), and with indocyanine green. The feasibility of this new method was assessed in comparison with the standard nanocoll.

Results

A lymphatic network between the place of injection of ICG and sentinel node was seen in infrared light. An area where a sentinel node was possibly located was confirmed by gamma probe. Sensitivity of this method was 100%.

Conclusion

SNB using ICG is a new, promising diagnostics technique. This procedure is not without drawbacks; nevertheless it opens new horizons in lymphatic network diagnostics.

Get Citation

Keywords

Sentinel node biopsy; Lymphatic flow; Breast cancer

About this article
Title

Sentinel node biopsy in breast cancer using infrared laser system first experience with PDE camera

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 16, No 3 (2011)

Pages

82-86

Published online

2011-05-01

DOI

10.1016/j.rpor.2011.02.005

Bibliographic record

Rep Pract Oncol Radiother 2011;16(3):82-86.

Keywords

Sentinel node biopsy
Lymphatic flow
Breast cancer

Authors

Karol Polom
Dawid Murawa
Michał Michalak
Paweł Murawa

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