open access

Vol 16, No 1 (2011)
Case reports
Published online: 2011-01-01
Submitted: 2010-10-13
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Anal canal plasmacytoma—An uncommon presentation site

Maria Inês Antunes, Laurentiu Bujor, Isabel Monteiro Grillo
DOI: 10.1016/j.rpor.2010.12.002
·
Rep Pract Oncol Radiother 2011;16(1):36-39.

open access

Vol 16, No 1 (2011)
Case reports
Published online: 2011-01-01
Submitted: 2010-10-13

Abstract

Background

Extramedullary plasmacytomas (EMP) are rare plasma cell tumors that arise outside the bone marrow. They are most often located in the head and neck region, but may also occur in the other locations. The lower gastrointestinal EMP represents less than 5% of all cases, and location in the anal canal is exceedingly rare.

Aim

We present an exceedingly rare case of anal canal plasmacytoma, aiming to achieve a better understanding of this rare entity.

Methods

We report a case of a 61-year-old man with a bulky mass in the anal canal. The lesion measured about 6[[ce:hsp sp="0.25"/]]cm and invaded in all layers of the anal canal wall. The biopsy was performed and revealed a round and plasmocitoid cell population with a solid growth pattern and necrosis. The tumoral cells have express CD79a and CD138 with lambda chains. There was no evidence of disease in other locations and these features were consistent with the diagnosis of an extra-osseous plasmacytoma. The patient was submitted to conformal radiotherapy 50.4[[ce:hsp sp="0.25"/]]Gy total dose, 1.8[[ce:hsp sp="0.25"/]]Gy per fraction. After 24 months, the patient is asymptomatic and the lesion has completely disappeared.

Conclusions

EMP accounts for approximately 3% of plasma cell malignancies. The median age is about 60 years, and the majority of patients are male. The treatment of choice for extramedullary plasmacytoma is radiation therapy in a dosage of about 50[[ce:hsp sp="0.25"/]]Gy. Patients should be followed-up for life with repeated bone marrow aspiration and protein studies to detect the development of multiple myeloma.

Abstract

Background

Extramedullary plasmacytomas (EMP) are rare plasma cell tumors that arise outside the bone marrow. They are most often located in the head and neck region, but may also occur in the other locations. The lower gastrointestinal EMP represents less than 5% of all cases, and location in the anal canal is exceedingly rare.

Aim

We present an exceedingly rare case of anal canal plasmacytoma, aiming to achieve a better understanding of this rare entity.

Methods

We report a case of a 61-year-old man with a bulky mass in the anal canal. The lesion measured about 6[[ce:hsp sp="0.25"/]]cm and invaded in all layers of the anal canal wall. The biopsy was performed and revealed a round and plasmocitoid cell population with a solid growth pattern and necrosis. The tumoral cells have express CD79a and CD138 with lambda chains. There was no evidence of disease in other locations and these features were consistent with the diagnosis of an extra-osseous plasmacytoma. The patient was submitted to conformal radiotherapy 50.4[[ce:hsp sp="0.25"/]]Gy total dose, 1.8[[ce:hsp sp="0.25"/]]Gy per fraction. After 24 months, the patient is asymptomatic and the lesion has completely disappeared.

Conclusions

EMP accounts for approximately 3% of plasma cell malignancies. The median age is about 60 years, and the majority of patients are male. The treatment of choice for extramedullary plasmacytoma is radiation therapy in a dosage of about 50[[ce:hsp sp="0.25"/]]Gy. Patients should be followed-up for life with repeated bone marrow aspiration and protein studies to detect the development of multiple myeloma.

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Keywords

Extramedullary plasmacytoma; Radiotherapy

About this article
Title

Anal canal plasmacytoma—An uncommon presentation site

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 16, No 1 (2011)

Pages

36-39

Published online

2011-01-01

DOI

10.1016/j.rpor.2010.12.002

Bibliographic record

Rep Pract Oncol Radiother 2011;16(1):36-39.

Keywords

Extramedullary plasmacytoma
Radiotherapy

Authors

Maria Inês Antunes
Laurentiu Bujor
Isabel Monteiro Grillo

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