open access

Vol 15, No 5 (2010)
Published online: 2010-09-01
Submitted: 2010-01-14
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Tracheal cancer: Role of radiation therapy

Marcin Hetnał, Alicja Kielaszek-Ćmiel, Magdalena Wolanin, Stanisław Korzeniowski, Piotr Brandys, Krzysztof Małecki, Beata Sas-Korczyńska, Monika Chłosta, Anna Kokoszka
DOI: 10.1016/j.rpor.2010.08.005
·
Rep Pract Oncol Radiother 2010;15(5):113-118.

open access

Vol 15, No 5 (2010)
Published online: 2010-09-01
Submitted: 2010-01-14

Abstract

Purpose

To assess the results of tracheal cancer patients treatment and factors influencing prognosis.

Background

Primary malignant neoplasms of the trachea are rare. The treatment of choice for tracheal carcinomas is resection. Radiation therapy is recommended as a part of radical treatment or for palliation of symptoms.

Materials and methods

Between 1962 and 2006, 50 patients diagnosed with tracheal cancer were treated at the Centre of Oncology in Krakow. The analysis focused on locoregional recurrence-free survival (LRRFS), disease free survival (DFS) and overall survival (OS). Survival rates, univariate and multivariate analyses of prognostic factors were performed using the Kaplan–Meier method, the log rank test and Cox's proportional hazard method, respectively.

For over 40 years, patients were treated using different modalities: surgery followed by radiotherapy (6%), radiotherapy (78%), chemoradiotherapy (8%), and symptomatic treatment (8%).

Results

The 5-year LRRFS was 18%, DFS was 15% and OS was 17%. gender (favoured females) was the only prognostic factor for LRRFS. For OS, the independent prognostic factors were performance status (favoured Karnofsky higher than 80), stage and year of start of the treatment (later than 1988 vs. earlier – 5-year OS 20% vs. 12%).

5-year OS in the following (strongly differentiated over the time) treatment modalities were: surgery followed by radiotherapy (66%), radiotherapy (16%), chemoradiotherapy (0%), and symptomatic treatment (0%).

Of 44 patients treated with radiotherapy symptomatic partial response was observed in 32 patients and follow-up imaging studies revealed complete response in 5 patients, partial response in 25, stable disease in 4 or progressive disease in 4.

Conclusions

Radical treatment in patients in early stage and good performance status seems to be correlated with the improvement of survival. However, despite the fact that results of treatment are poor, radiotherapy offers symptomatic improvement.

Abstract

Purpose

To assess the results of tracheal cancer patients treatment and factors influencing prognosis.

Background

Primary malignant neoplasms of the trachea are rare. The treatment of choice for tracheal carcinomas is resection. Radiation therapy is recommended as a part of radical treatment or for palliation of symptoms.

Materials and methods

Between 1962 and 2006, 50 patients diagnosed with tracheal cancer were treated at the Centre of Oncology in Krakow. The analysis focused on locoregional recurrence-free survival (LRRFS), disease free survival (DFS) and overall survival (OS). Survival rates, univariate and multivariate analyses of prognostic factors were performed using the Kaplan–Meier method, the log rank test and Cox's proportional hazard method, respectively.

For over 40 years, patients were treated using different modalities: surgery followed by radiotherapy (6%), radiotherapy (78%), chemoradiotherapy (8%), and symptomatic treatment (8%).

Results

The 5-year LRRFS was 18%, DFS was 15% and OS was 17%. gender (favoured females) was the only prognostic factor for LRRFS. For OS, the independent prognostic factors were performance status (favoured Karnofsky higher than 80), stage and year of start of the treatment (later than 1988 vs. earlier – 5-year OS 20% vs. 12%).

5-year OS in the following (strongly differentiated over the time) treatment modalities were: surgery followed by radiotherapy (66%), radiotherapy (16%), chemoradiotherapy (0%), and symptomatic treatment (0%).

Of 44 patients treated with radiotherapy symptomatic partial response was observed in 32 patients and follow-up imaging studies revealed complete response in 5 patients, partial response in 25, stable disease in 4 or progressive disease in 4.

Conclusions

Radical treatment in patients in early stage and good performance status seems to be correlated with the improvement of survival. However, despite the fact that results of treatment are poor, radiotherapy offers symptomatic improvement.

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Keywords

Tracheal cancer; Radiotherapy; Staging; Prognostic factors

About this article
Title

Tracheal cancer: Role of radiation therapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 15, No 5 (2010)

Pages

113-118

Published online

2010-09-01

DOI

10.1016/j.rpor.2010.08.005

Bibliographic record

Rep Pract Oncol Radiother 2010;15(5):113-118.

Keywords

Tracheal cancer
Radiotherapy
Staging
Prognostic factors

Authors

Marcin Hetnał
Alicja Kielaszek-Ćmiel
Magdalena Wolanin
Stanisław Korzeniowski
Piotr Brandys
Krzysztof Małecki
Beata Sas-Korczyńska
Monika Chłosta
Anna Kokoszka

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