open access

Vol 14, No 2 (2009)
Untitled
Published online: 2009-03-01
Submitted: 2009-01-20
Get Citation

The importance of radiotherapy in paediatric atypical teratoid rhabdoid tumour of the brain

Elżbieta KORAB CHRZANOWSKA, Joanna BARTOSZEWSKA, Monika DROGOSIEWICZ, Stanisław KWIATKOWSKI, Anna SKOWROŃSKA-GARDAS
DOI: 10.1016/S1507-1367(10)60022-3
·
Rep Pract Oncol Radiother 2009;14(2):53-57.

open access

Vol 14, No 2 (2009)
Untitled
Published online: 2009-03-01
Submitted: 2009-01-20

Abstract

Background

Atypical teratoid rhabdoid tumours (ATRT) are very rare children's cancers. Approximately 200 cases of ATRT located in the central nervous system have been described in the literature up till now.

Aim

The aim of this report was to analyze the results of treatment of 8 children with these very rare neoplasms of the central nervous system, who were treated according to the Polish Paediatric Brain Tumour Group protocol.

Material and Methods

Eight children aged from 4 months to 22 years, 5 girls, 3 boys with ATRT of the central nervous system are presented. All children have been operated on and received multidrug chemotherapy; 5 children received radiotherapy as well. In all craniospinal irradiation was applied, in doses of 35 Gy to the whole axis and 55 Gy to tumour boost.

Results

Five patients died and 3 children are still alive. The progression-free survival of all 8 patients was 3 to 73 months. The overall survival was 5 to 73 months. All living children received radiotherapy. Two of them had total surgical resection and one partial.

Conclusions

We conclude that radiotherapy prolonged survival in ATRT and should be incorporated in all treatment protocols for patients with this diagnosis.

Abstract

Background

Atypical teratoid rhabdoid tumours (ATRT) are very rare children's cancers. Approximately 200 cases of ATRT located in the central nervous system have been described in the literature up till now.

Aim

The aim of this report was to analyze the results of treatment of 8 children with these very rare neoplasms of the central nervous system, who were treated according to the Polish Paediatric Brain Tumour Group protocol.

Material and Methods

Eight children aged from 4 months to 22 years, 5 girls, 3 boys with ATRT of the central nervous system are presented. All children have been operated on and received multidrug chemotherapy; 5 children received radiotherapy as well. In all craniospinal irradiation was applied, in doses of 35 Gy to the whole axis and 55 Gy to tumour boost.

Results

Five patients died and 3 children are still alive. The progression-free survival of all 8 patients was 3 to 73 months. The overall survival was 5 to 73 months. All living children received radiotherapy. Two of them had total surgical resection and one partial.

Conclusions

We conclude that radiotherapy prolonged survival in ATRT and should be incorporated in all treatment protocols for patients with this diagnosis.

Get Citation

Keywords

atypical teratoid rhabdoid tumour; children; radiotherapy

About this article
Title

The importance of radiotherapy in paediatric atypical teratoid rhabdoid tumour of the brain

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 14, No 2 (2009)

Pages

53-57

Published online

2009-03-01

DOI

10.1016/S1507-1367(10)60022-3

Bibliographic record

Rep Pract Oncol Radiother 2009;14(2):53-57.

Keywords

atypical teratoid rhabdoid tumour
children
radiotherapy

Authors

Elżbieta KORAB CHRZANOWSKA
Joanna BARTOSZEWSKA
Monika DROGOSIEWICZ
Stanisław KWIATKOWSKI
Anna SKOWROŃSKA-GARDAS

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl