open access

Vol 13, No 4 (2008)
Untitled
Published online: 2008-07-01
Submitted: 2007-02-21
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Tumour-infiltrating CD4 and CD8 T lymphocytes in breast cancer

Iwona GISTEREK, Irena FRYDECKA, Grzegorz ŚWIĄTONIOWSKI, Sebastian FIDLER, Jan KORNAFEL
DOI: 10.1016/S1507-1367(10)60011-9
·
Rep Pract Oncol Radiother 2008;13(4):206-209.

open access

Vol 13, No 4 (2008)
Untitled
Published online: 2008-07-01
Submitted: 2007-02-21

Abstract

Lymphocytes are cells circulating between the blood and tissues. It has been stated that a correlation exists between immune infiltrate and breast cancer. These tumours are infiltrated by T cells, B cells, natural killer cells and macrophages. The infiltrating T cells are of helper (CD4+) and cytotoxic (CD8+) phenotypes. Specific immunity mediated by cytolytic T lymphocytes is suspected of playing an anticancer role. It is widely known that regional lymph nodes are an important immunological defence or “barrier” against tumour expansion. Some authors have reported that in cancer patients natural killer (NK) cells and CD8+ T cells are diminished in regional lymph nodes, particularly those involved by the tumour.

In the presented study the authors review current knowledge on this problem and the possibility of using successful immunotherapy with monoclonal antibodies for breast cancer.

Abstract

Lymphocytes are cells circulating between the blood and tissues. It has been stated that a correlation exists between immune infiltrate and breast cancer. These tumours are infiltrated by T cells, B cells, natural killer cells and macrophages. The infiltrating T cells are of helper (CD4+) and cytotoxic (CD8+) phenotypes. Specific immunity mediated by cytolytic T lymphocytes is suspected of playing an anticancer role. It is widely known that regional lymph nodes are an important immunological defence or “barrier” against tumour expansion. Some authors have reported that in cancer patients natural killer (NK) cells and CD8+ T cells are diminished in regional lymph nodes, particularly those involved by the tumour.

In the presented study the authors review current knowledge on this problem and the possibility of using successful immunotherapy with monoclonal antibodies for breast cancer.

Get Citation

Keywords

breast cancer, CD4+, CD8+

About this article
Title

Tumour-infiltrating CD4 and CD8 T lymphocytes in breast cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 13, No 4 (2008)

Pages

206-209

Published online

2008-07-01

DOI

10.1016/S1507-1367(10)60011-9

Bibliographic record

Rep Pract Oncol Radiother 2008;13(4):206-209.

Keywords

breast cancer
CD4+
CD8+

Authors

Iwona GISTEREK
Irena FRYDECKA
Grzegorz ŚWIĄTONIOWSKI
Sebastian FIDLER
Jan KORNAFEL

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