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Vol 13, No 4 (2008)
Untitled
Published online: 2008-07-01
Submitted: 2008-02-23
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Irradiation of malignant exophthalmos in the course of Graves Basedow disease

Aneta L. ZYGULSKA, Barbara KOWALSKA
DOI: 10.1016/S1507-1367(10)60008-9
·
Rep Pract Oncol Radiother 2008;13(4):187-195.

open access

Vol 13, No 4 (2008)
Untitled
Published online: 2008-07-01
Submitted: 2008-02-23

Abstract

Aim

To present results of irradiation of ophthalmopathy in the course of Graves-Basedow disease performed in the Radiotherapy Laboratory in University Children's Hospital in Cracow by staff of the Oncology Clinic, Collegium Medicum Jagiellonian University (CM UJ).

Material and Method

During the period of 2000–2003 therapeutic irradiation of the retrobulbar area was performed in 121 patients with malignant exophthalmos using a total dose of 20 Gy/ 10 fractions of 6 MV photonic beam in the Radiotherapy Laboratory in University Children's Hospital in Cracow. Execution of the treatment plan was controlled by in vivo dose measurements using semiconducting detectors, MOSFET type. Radiotherapy was preceded by intravenous corticosteroid therapy (Solu Medrol) with a dose of 2g/ week for 4 weeks.

Results

During the irradiation treatment 9 patients (7.4%) developed an acute post-radiation reaction of transient character. Ophthalmological control examination revealed an improvement in 97 patients (80.2%) in the form of reduction or total regression of ophthalmopathy symptoms; in 21 other patients (17.3%) stabilization was noted and progression in 3 (2.5%).

Conclusions

Radiotherapy is a well-tolerated method of ophthalmopathy treatment in the cour se of Graves-Basedow disease. Efficacy of radiotherapy as an exclusive method of malignant exophthalmos treatment seems to be lower in comparison to irradiation combined with corticosteroid therapy.

Abstract

Aim

To present results of irradiation of ophthalmopathy in the course of Graves-Basedow disease performed in the Radiotherapy Laboratory in University Children's Hospital in Cracow by staff of the Oncology Clinic, Collegium Medicum Jagiellonian University (CM UJ).

Material and Method

During the period of 2000–2003 therapeutic irradiation of the retrobulbar area was performed in 121 patients with malignant exophthalmos using a total dose of 20 Gy/ 10 fractions of 6 MV photonic beam in the Radiotherapy Laboratory in University Children's Hospital in Cracow. Execution of the treatment plan was controlled by in vivo dose measurements using semiconducting detectors, MOSFET type. Radiotherapy was preceded by intravenous corticosteroid therapy (Solu Medrol) with a dose of 2g/ week for 4 weeks.

Results

During the irradiation treatment 9 patients (7.4%) developed an acute post-radiation reaction of transient character. Ophthalmological control examination revealed an improvement in 97 patients (80.2%) in the form of reduction or total regression of ophthalmopathy symptoms; in 21 other patients (17.3%) stabilization was noted and progression in 3 (2.5%).

Conclusions

Radiotherapy is a well-tolerated method of ophthalmopathy treatment in the cour se of Graves-Basedow disease. Efficacy of radiotherapy as an exclusive method of malignant exophthalmos treatment seems to be lower in comparison to irradiation combined with corticosteroid therapy.

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Keywords

malignant exophthalmos; radiotherapy; combined treatment

About this article
Title

Irradiation of malignant exophthalmos in the course of Graves Basedow disease

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 13, No 4 (2008)

Pages

187-195

Published online

2008-07-01

DOI

10.1016/S1507-1367(10)60008-9

Bibliographic record

Rep Pract Oncol Radiother 2008;13(4):187-195.

Keywords

malignant exophthalmos
radiotherapy
combined treatment

Authors

Aneta L. ZYGULSKA
Barbara KOWALSKA

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