open access

Vol 12, No 3 (2007)
Untitled
Published online: 2007-05-01
Submitted: 2007-01-17
Get Citation

Intensive care and outcome in children undergoing haematopoietic stem cell transplantation

Lynne M. Ball
DOI: 10.1016/S1507-1367(10)60054-5
·
Rep Pract Oncol Radiother 2007;12(3):171-174.

open access

Vol 12, No 3 (2007)
Untitled
Published online: 2007-05-01
Submitted: 2007-01-17

Abstract

Aim

To review literature data concerning treatment of procedure-related complications in the intensive care unit in children undergoing allogeneic haematopoietic stem cell transplantation with a focus on clinical results, limitations of studies, recent improvements and remaining problems.

Materials/Methods

A review of PubMed references based on evidence-based recommendations and own experience.

Results

Modern ICU care both for adults and children undergoing HSCT has improved in the last decade. However, multi-organ system failure and those requiring mechanical ventilation have the worst outcome. Within the paediatric setting the majority of children are transferred for respiratory support and pulmonary complications. Septic shock and its consequences are associated with far fewer admissions to the ICU. The role of the ICU requires constant revision as protocols and treatments change both in the HSCT unit as well as in intensive care.

Conclusions

An adequate scoring system such as an adapted O-PRISM should be developed and would lead to the possibility of multi-centre comparative data acquisition and develop future studies in this critically ill group of patients.

Abstract

Aim

To review literature data concerning treatment of procedure-related complications in the intensive care unit in children undergoing allogeneic haematopoietic stem cell transplantation with a focus on clinical results, limitations of studies, recent improvements and remaining problems.

Materials/Methods

A review of PubMed references based on evidence-based recommendations and own experience.

Results

Modern ICU care both for adults and children undergoing HSCT has improved in the last decade. However, multi-organ system failure and those requiring mechanical ventilation have the worst outcome. Within the paediatric setting the majority of children are transferred for respiratory support and pulmonary complications. Septic shock and its consequences are associated with far fewer admissions to the ICU. The role of the ICU requires constant revision as protocols and treatments change both in the HSCT unit as well as in intensive care.

Conclusions

An adequate scoring system such as an adapted O-PRISM should be developed and would lead to the possibility of multi-centre comparative data acquisition and develop future studies in this critically ill group of patients.

Get Citation

Keywords

intensive care; transplant related complications; allogeneic HSCT in children

About this article
Title

Intensive care and outcome in children undergoing haematopoietic stem cell transplantation

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 12, No 3 (2007)

Pages

171-174

Published online

2007-05-01

DOI

10.1016/S1507-1367(10)60054-5

Bibliographic record

Rep Pract Oncol Radiother 2007;12(3):171-174.

Keywords

intensive care
transplant related complications
allogeneic HSCT in children

Authors

Lynne M. Ball

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl