open access

Vol 12, No 2 (2007)
Untitled
Published online: 2007-03-01
Submitted: 2006-10-23
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Melatonin as a protective agent in spinal cord damage after gamma irradiation

Sara Aghazadeh, Mahnaz Azarnia, Alireza Shirazi, Seied Rabie Mahdavi, Bagher Minaee Zangii
DOI: 10.1016/S1507-1367(10)60045-4
·
Rep Pract Oncol Radiother 2007;12(2):95-99.

open access

Vol 12, No 2 (2007)
Untitled
Published online: 2007-03-01
Submitted: 2006-10-23

Abstract

Background

Radiation causes serious damage to the spinal cord and several agents are used for protection.

Aim

The aim of this study was to assess the neuro-radioprotective effect of melatonin on the cervical spinal cord.

Materials/Methods

A sample of 32 male adult Wistar albino rats weighing 200–250g was used. They were divided into four groups of eight animals: control, melatonin (30mg/kg per day) and radiation (single Gamma dose of 10Gy) groups and the group that received radiation plus melatonin. After 72 hours, all rats were sacrificed for histopathological analysis of malondialdehyde, glutathione and protein biochemicals.

Results

Malondialdehyde and protein levels were decreased after melatonin treatment while glutathione level was increased (p<0.005). Overall histopathological changes were markedly decreased after melatonin treatment in comparison to radiation group (p<0.05).

Conclusions

In conclusion melatonin may be useful in preventing the spinal cord against radiation toxicity due to its potential for free oxygen radical scavenging.

Abstract

Background

Radiation causes serious damage to the spinal cord and several agents are used for protection.

Aim

The aim of this study was to assess the neuro-radioprotective effect of melatonin on the cervical spinal cord.

Materials/Methods

A sample of 32 male adult Wistar albino rats weighing 200–250g was used. They were divided into four groups of eight animals: control, melatonin (30mg/kg per day) and radiation (single Gamma dose of 10Gy) groups and the group that received radiation plus melatonin. After 72 hours, all rats were sacrificed for histopathological analysis of malondialdehyde, glutathione and protein biochemicals.

Results

Malondialdehyde and protein levels were decreased after melatonin treatment while glutathione level was increased (p<0.005). Overall histopathological changes were markedly decreased after melatonin treatment in comparison to radiation group (p<0.05).

Conclusions

In conclusion melatonin may be useful in preventing the spinal cord against radiation toxicity due to its potential for free oxygen radical scavenging.

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Keywords

melatonin; free radical; radiation protection; MDA; GSH

About this article
Title

Melatonin as a protective agent in spinal cord damage after gamma irradiation

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 12, No 2 (2007)

Pages

95-99

Published online

2007-03-01

DOI

10.1016/S1507-1367(10)60045-4

Bibliographic record

Rep Pract Oncol Radiother 2007;12(2):95-99.

Keywords

melatonin
free radical
radiation protection
MDA
GSH

Authors

Sara Aghazadeh
Mahnaz Azarnia
Alireza Shirazi
Seied Rabie Mahdavi
Bagher Minaee Zangii

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