open access

Vol 12, No 1 (2007)
Untitled
Published online: 2007-01-01
Submitted: 2006-11-21
Get Citation

Cryptococcal neuroinfection in an adult patient with chronic B-lymphatic leukaemia with medium risk – a case report

Ladislav Slovacek, Ladislav Jebavy
DOI: 10.1016/S1507-1367(10)60042-9
·
Rep Pract Oncol Radiother 2007;12(1):61-64.

open access

Vol 12, No 1 (2007)
Untitled
Published online: 2007-01-01
Submitted: 2006-11-21

Abstract

Background

Chronic B-lymphatic leukaemia is one reason for the development of secondary immunodeficiency due to a decrease of antibody immune activity (hypogammaglobulinaemia) and a decrease of T-cell immunity. Cryptococcosis is an infectious disease induced by Cryptococcus neoformans fungus. A high incidence was revealed in immunocompromised patients, above all in patients with AIDS or with haematological malignancies usually with a primary focus in the lungs and with characteristic spread into the cerebral dura mater and rarely into the kidneys, prostate, liver, bones and skin.

Aim

The aim of the study was to report a case of fatal Cryptococcus neoformans meningitis in an adult patient with chronic B-lymphatic leukaemia.

Material/Methods

It is a case study report of a 74-year-old man who presented with a four-year history of B-CLL admitted to the Department of Clinical Haematology with suspected neuroinfection. Symptoms included headache and sleepiness. Diagnostic work-up comprised neurological investigation, magnetic resonance imaging of the brain, lumbal puncture with microscopic, cytological and biochemical investigations of cerebrospinal fluid and investigations of blood serum for borellia, toxoplasma, Cytomegalovirus and Epstein-Barrs virus. Cultural investigation of the fluid verified two colonies of the fungus Cryptococcus neoformans. Despite intravenous and intrathecal administration of antibiotics and steroids the patient died due to septic shock.

Conclusions

Prognosis of cryptococcosis is very serious especially in immunocompromised patients and in the case of disseminated form is always infaust.

Abstract

Background

Chronic B-lymphatic leukaemia is one reason for the development of secondary immunodeficiency due to a decrease of antibody immune activity (hypogammaglobulinaemia) and a decrease of T-cell immunity. Cryptococcosis is an infectious disease induced by Cryptococcus neoformans fungus. A high incidence was revealed in immunocompromised patients, above all in patients with AIDS or with haematological malignancies usually with a primary focus in the lungs and with characteristic spread into the cerebral dura mater and rarely into the kidneys, prostate, liver, bones and skin.

Aim

The aim of the study was to report a case of fatal Cryptococcus neoformans meningitis in an adult patient with chronic B-lymphatic leukaemia.

Material/Methods

It is a case study report of a 74-year-old man who presented with a four-year history of B-CLL admitted to the Department of Clinical Haematology with suspected neuroinfection. Symptoms included headache and sleepiness. Diagnostic work-up comprised neurological investigation, magnetic resonance imaging of the brain, lumbal puncture with microscopic, cytological and biochemical investigations of cerebrospinal fluid and investigations of blood serum for borellia, toxoplasma, Cytomegalovirus and Epstein-Barrs virus. Cultural investigation of the fluid verified two colonies of the fungus Cryptococcus neoformans. Despite intravenous and intrathecal administration of antibiotics and steroids the patient died due to septic shock.

Conclusions

Prognosis of cryptococcosis is very serious especially in immunocompromised patients and in the case of disseminated form is always infaust.

Get Citation

Keywords

cryptococcosis; chronic B-lymphatic leukaemia; meningitis

About this article
Title

Cryptococcal neuroinfection in an adult patient with chronic B-lymphatic leukaemia with medium risk – a case report

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 12, No 1 (2007)

Pages

61-64

Published online

2007-01-01

DOI

10.1016/S1507-1367(10)60042-9

Bibliographic record

Rep Pract Oncol Radiother 2007;12(1):61-64.

Keywords

cryptococcosis
chronic B-lymphatic leukaemia
meningitis

Authors

Ladislav Slovacek
Ladislav Jebavy

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl