open access
Classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy
open access
Abstract
Aim
Analysis of classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy.
Materials/Methods
In the years 1985–1999, 705 patients underwent postoperative radiotherapy due to endometrial cancer: 529 patients with FIGO stage I and 176 with FIGO stage II cancer. Mean age was 58 years. In 96% of patients endometrioid adenocarcinoma was found. In 49.9% the cancer had a high, in 27.9% a medium, and in 22.2% a low degree of differentiation.
Results
82% of patients had 5-year disease-free survival. In univariate analysis a significantly higher rate of disease-free survival was observed in: patients younger than 60, with moderately and well differentiated cancers, with stage I endometrioid adenocarcinoma with less than 50% myometrial invasion. In multivariate analysis degree of cancer differentiation was the only independent prognostic factor.
Conclusions
In a group of patients with non-advanced endometrial cancer treated with postoperative radiotherapy, degree of cancer differentiation is the primary prognostic factor.
Abstract
Aim
Analysis of classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy.
Materials/Methods
In the years 1985–1999, 705 patients underwent postoperative radiotherapy due to endometrial cancer: 529 patients with FIGO stage I and 176 with FIGO stage II cancer. Mean age was 58 years. In 96% of patients endometrioid adenocarcinoma was found. In 49.9% the cancer had a high, in 27.9% a medium, and in 22.2% a low degree of differentiation.
Results
82% of patients had 5-year disease-free survival. In univariate analysis a significantly higher rate of disease-free survival was observed in: patients younger than 60, with moderately and well differentiated cancers, with stage I endometrioid adenocarcinoma with less than 50% myometrial invasion. In multivariate analysis degree of cancer differentiation was the only independent prognostic factor.
Conclusions
In a group of patients with non-advanced endometrial cancer treated with postoperative radiotherapy, degree of cancer differentiation is the primary prognostic factor.
Keywords
Non-advanced endometrial cancer; Postoperative radiotherapy; Prognostic factors
About this articleTitle
Classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
169-174
Published online
2006-01-01
DOI
10.1016/S1507-1367(06)71061-6
Bibliographic record
Rep Pract Oncol Radiother 2006;11(4):169-174.
Keywords
Non-advanced endometrial cancer
Postoperative radiotherapy
Prognostic factors
Authors
Kazimierz Karolewski
Andrzej Michalak
Zbigniew Kojs
Jerzy Jakubowicz
Krzysztof Urbański