open access

Vol 11, No 4 (2006)
Published online: 2006-01-01
Submitted: 2004-11-16
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Classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy

Kazimierz Karolewski, Andrzej Michalak, Zbigniew Kojs, Jerzy Jakubowicz, Krzysztof Urbański
DOI: 10.1016/S1507-1367(06)71061-6
·
Rep Pract Oncol Radiother 2006;11(4):169-174.

open access

Vol 11, No 4 (2006)
Published online: 2006-01-01
Submitted: 2004-11-16

Abstract

Aim

Analysis of classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy.

Materials/Methods

In the years 1985–1999, 705 patients underwent postoperative radiotherapy due to endometrial cancer: 529 patients with FIGO stage I and 176 with FIGO stage II cancer. Mean age was 58 years. In 96% of patients endometrioid adenocarcinoma was found. In 49.9% the cancer had a high, in 27.9% a medium, and in 22.2% a low degree of differentiation.

Results

82% of patients had 5-year disease-free survival. In univariate analysis a significantly higher rate of disease-free survival was observed in: patients younger than 60, with moderately and well differentiated cancers, with stage I endometrioid adenocarcinoma with less than 50% myometrial invasion. In multivariate analysis degree of cancer differentiation was the only independent prognostic factor.

Conclusions

In a group of patients with non-advanced endometrial cancer treated with postoperative radiotherapy, degree of cancer differentiation is the primary prognostic factor.

Abstract

Aim

Analysis of classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy.

Materials/Methods

In the years 1985–1999, 705 patients underwent postoperative radiotherapy due to endometrial cancer: 529 patients with FIGO stage I and 176 with FIGO stage II cancer. Mean age was 58 years. In 96% of patients endometrioid adenocarcinoma was found. In 49.9% the cancer had a high, in 27.9% a medium, and in 22.2% a low degree of differentiation.

Results

82% of patients had 5-year disease-free survival. In univariate analysis a significantly higher rate of disease-free survival was observed in: patients younger than 60, with moderately and well differentiated cancers, with stage I endometrioid adenocarcinoma with less than 50% myometrial invasion. In multivariate analysis degree of cancer differentiation was the only independent prognostic factor.

Conclusions

In a group of patients with non-advanced endometrial cancer treated with postoperative radiotherapy, degree of cancer differentiation is the primary prognostic factor.

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Keywords

Non-advanced endometrial cancer; Postoperative radiotherapy; Prognostic factors

About this article
Title

Classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 11, No 4 (2006)

Pages

169-174

Published online

2006-01-01

DOI

10.1016/S1507-1367(06)71061-6

Bibliographic record

Rep Pract Oncol Radiother 2006;11(4):169-174.

Keywords

Non-advanced endometrial cancer
Postoperative radiotherapy
Prognostic factors

Authors

Kazimierz Karolewski
Andrzej Michalak
Zbigniew Kojs
Jerzy Jakubowicz
Krzysztof Urbański

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