open access

Vol 10, No 4 (2005)
Original Paper
Published online: 2005-01-01
Submitted: 2004-04-07
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The role of oestrogen receptor β in invasive breast cancer

Maria Litwiniuk, Violetta Filas, Beata Dziekan, Jerzy Moczko, Jan Bręborowicz
DOI: 10.1016/S1507-1367(05)71090-7
·
Rep Pract Oncol Radiother 2005;10(4):173-177.

open access

Vol 10, No 4 (2005)
Original Paper
Published online: 2005-01-01
Submitted: 2004-04-07

Abstract

Background

The presence of estrogen receptor (ER) in breast cancer cell is a good prognostic factor. It is also a predictive factor used in hormonal therapy.

Aim

To evaluate the expression of oestrogen receptors α and β (ERα and ERβ) in the neoplastic tissues of patients with invasive breast cancer and to determine whether ERβ expression may be correlated with some clinical parameters and biological markers.

Materials/Methods

Paraffin embedded tissues from 67 patients with breast cancer were used in this study. Monoclonal antibodies against α oestrogen receptors, progesterone receptors (DakoCytomation) and polyclonal antibodies against β oestrogen receptors (CHEMICON) were used. The EnVision detection system was applied.

Results

Expression of ERα was demonstrated in 57% of all patients, while in patients over 50 years it was higher – 71%. Expression of ERβ was demonstrated in 48% of patients and this percentage was not dependent on the age of the patients. In tumours expressing ERβ, expression of p53 and Ki-67 was less common. In addition, these tumours were of a lower grade of malignancy.

Conclusions

Our results demonstrate a negative correlation between the expression of ERβ and the expression of p53 and Ki-67. The expression of ERβ may be a good prognostic indicator.

Abstract

Background

The presence of estrogen receptor (ER) in breast cancer cell is a good prognostic factor. It is also a predictive factor used in hormonal therapy.

Aim

To evaluate the expression of oestrogen receptors α and β (ERα and ERβ) in the neoplastic tissues of patients with invasive breast cancer and to determine whether ERβ expression may be correlated with some clinical parameters and biological markers.

Materials/Methods

Paraffin embedded tissues from 67 patients with breast cancer were used in this study. Monoclonal antibodies against α oestrogen receptors, progesterone receptors (DakoCytomation) and polyclonal antibodies against β oestrogen receptors (CHEMICON) were used. The EnVision detection system was applied.

Results

Expression of ERα was demonstrated in 57% of all patients, while in patients over 50 years it was higher – 71%. Expression of ERβ was demonstrated in 48% of patients and this percentage was not dependent on the age of the patients. In tumours expressing ERβ, expression of p53 and Ki-67 was less common. In addition, these tumours were of a lower grade of malignancy.

Conclusions

Our results demonstrate a negative correlation between the expression of ERβ and the expression of p53 and Ki-67. The expression of ERβ may be a good prognostic indicator.

Get Citation

Keywords

estrogen receptor β; breast cancer; immunohistochemistry

About this article
Title

The role of oestrogen receptor β in invasive breast cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 10, No 4 (2005)

Pages

173-177

Published online

2005-01-01

DOI

10.1016/S1507-1367(05)71090-7

Bibliographic record

Rep Pract Oncol Radiother 2005;10(4):173-177.

Keywords

estrogen receptor β
breast cancer
immunohistochemistry

Authors

Maria Litwiniuk
Violetta Filas
Beata Dziekan
Jerzy Moczko
Jan Bręborowicz

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