open access

Vol 10, No 3 (2005)
Original Paper
Published online: 2005-01-01
Submitted: 2004-12-20
Get Citation

Conformal radiotherapy in children with low-grade brain tumours: treatment results and toxicity

Anna Skowrońska-Gardas, Marzanna Chojnacka, Katarzyna Pędziwiatr
DOI: 10.1016/S1507-1367(05)71086-5
·
Rep Pract Oncol Radiother 2005;10(3):131-140.

open access

Vol 10, No 3 (2005)
Original Paper
Published online: 2005-01-01
Submitted: 2004-12-20

Abstract

Background

The conformal radiotherapy technique is a particularly important method for the treatment of children with localized low-grade brain tumours, whose prognosis, with regard to long-term survival is often excellent and should be accompanied by the smallest possible risk of toxicity.

Aim

The results of 3-D conformal radiotherapy in children with low-grade astrocytoma and craniopharyngioma, treated in our department to present.

Materials/Methods

Between 1997–2001, 20 children, aged between 3.5 and 18 years, with low-grade brain tumours (8 craniopharyngioma and 12 low-grade astrocytoma) were treated with conformal radiotherapy. In the craniopharyngioma group, all patients were irradiated owing to tumour recurrence, after multiple surgeries, and were seriously handicapped before the commencement of radiotherapy. Patients with astrocytoma were treated after chemotherapy, partial surgery or biopsy only.

Results

All patients with craniopharyngioma survived with no recurrence (5) or with a stable disease state (3). Radiation related complications were not observed. Four patients with astrocytoma died, due to progressive disease (3) or chemotherapy related complications (1). Two patients are living with dissemination to the CNS, 4 with no recurrence and 2 have stabilized. Late complications after radiotherapy were not observed.

Conclusions

Three-dimensional radiation therapy is a safe and successful method for the combined treatment of children with low-grade brain tumours. The risk of radiotherapy related complications is relatively low.

Abstract

Background

The conformal radiotherapy technique is a particularly important method for the treatment of children with localized low-grade brain tumours, whose prognosis, with regard to long-term survival is often excellent and should be accompanied by the smallest possible risk of toxicity.

Aim

The results of 3-D conformal radiotherapy in children with low-grade astrocytoma and craniopharyngioma, treated in our department to present.

Materials/Methods

Between 1997–2001, 20 children, aged between 3.5 and 18 years, with low-grade brain tumours (8 craniopharyngioma and 12 low-grade astrocytoma) were treated with conformal radiotherapy. In the craniopharyngioma group, all patients were irradiated owing to tumour recurrence, after multiple surgeries, and were seriously handicapped before the commencement of radiotherapy. Patients with astrocytoma were treated after chemotherapy, partial surgery or biopsy only.

Results

All patients with craniopharyngioma survived with no recurrence (5) or with a stable disease state (3). Radiation related complications were not observed. Four patients with astrocytoma died, due to progressive disease (3) or chemotherapy related complications (1). Two patients are living with dissemination to the CNS, 4 with no recurrence and 2 have stabilized. Late complications after radiotherapy were not observed.

Conclusions

Three-dimensional radiation therapy is a safe and successful method for the combined treatment of children with low-grade brain tumours. The risk of radiotherapy related complications is relatively low.

Get Citation

Keywords

conformal radiotherapy; brain tumours; craniopharyngioma; astrocytoma; children

About this article
Title

Conformal radiotherapy in children with low-grade brain tumours: treatment results and toxicity

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 10, No 3 (2005)

Pages

131-140

Published online

2005-01-01

DOI

10.1016/S1507-1367(05)71086-5

Bibliographic record

Rep Pract Oncol Radiother 2005;10(3):131-140.

Keywords

conformal radiotherapy
brain tumours
craniopharyngioma
astrocytoma
children

Authors

Anna Skowrońska-Gardas
Marzanna Chojnacka
Katarzyna Pędziwiatr

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl