Different schemes of B-cell chronic lymphocytic leukaemia (B-CLL) treatment in the population affected by the Chernobyl accident

Abstract

Background

Remarkable advance in the knowledge of the biology and treatment of chronic lymphocytic leukaemia (CLL) has been noted in recent years. CLL resembles several heterogeneous diseases with variable morphological features. New agents with antileukemic activity have been introduced recently for CLL patients, which improved the treatment results. Fludarabin has shown its efficacy in CLL both as a treatment of choice and in combination with conventional cytostatic agents. Clinical and haematological features of B-CLL in persons affected by the Chernobyl accident in the last period are presented.

Aim

The aim of this study was the comparison of two chemotherapy different schemes for B-CLL treatment.

Materials/Methods

The study was based on 32 patients with diagnosis of B-CLL who were treated at the Hematology Department. Depending upon the protocol all patients were classified in two subgroups: I – fludarabine monotherapy treatment, II – fludarabine with combination with other chemotherapy preparations.

Results

Of the treatment are analyzed for 16 patients after different chemotherapy regimens. A combined fludarabine and cyclophosphamide regimen has been shown to improve long-term complete and partial remission in the majority of patients as compared with a more conservative approach.