open access

Vol 10, No 1 (2005)
Published online: 2005-01-01
Submitted: 2004-08-06
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Effect of depth on radiation-induced cell damage in a water phantom

Krzysztof Ślosarek, Maria Konopacka, Jacek Rogoliński, Małgorzata Latocha, Aleksander Sochanik
DOI: 10.1016/S1507-1367(05)71080-4
·
Rep Pract Oncol Radiother 2005;10(1):37-41.

open access

Vol 10, No 1 (2005)
Published online: 2005-01-01
Submitted: 2004-08-06

Abstract

Aim

The paper describes the effect of medium depth on radiation-induced genetic damage to SK-mel cultured cells placed inside a water phantom as measured by the number of cells with micronuclei formed and apoptoses seen in these cells.

Materials/Methods

The energy of photon radiation used was 6 MV; cells placed at various depths were irradiated with the same dose (5 Gy).

Results/Conclusions

Depending on medium depth, differences were noted in the number of damaged cells: ca.30% more affected cells were seen at a depth of 25 cm as compared to a depth of 5 cm. With increasing depth also the radiation energy spectrum changes. This is probably responsible for the observed effect. It should be taken into consideration in both clinical practice and in treatment planning.

Abstract

Aim

The paper describes the effect of medium depth on radiation-induced genetic damage to SK-mel cultured cells placed inside a water phantom as measured by the number of cells with micronuclei formed and apoptoses seen in these cells.

Materials/Methods

The energy of photon radiation used was 6 MV; cells placed at various depths were irradiated with the same dose (5 Gy).

Results/Conclusions

Depending on medium depth, differences were noted in the number of damaged cells: ca.30% more affected cells were seen at a depth of 25 cm as compared to a depth of 5 cm. With increasing depth also the radiation energy spectrum changes. This is probably responsible for the observed effect. It should be taken into consideration in both clinical practice and in treatment planning.

Get Citation

Keywords

scattered radiation; energy spectrum; cytogenetic damage

About this article
Title

Effect of depth on radiation-induced cell damage in a water phantom

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 10, No 1 (2005)

Pages

37-41

Published online

2005-01-01

DOI

10.1016/S1507-1367(05)71080-4

Bibliographic record

Rep Pract Oncol Radiother 2005;10(1):37-41.

Keywords

scattered radiation
energy spectrum
cytogenetic damage

Authors

Krzysztof Ślosarek
Maria Konopacka
Jacek Rogoliński
Małgorzata Latocha
Aleksander Sochanik

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