open access

Vol 9, No 5 (2004)
Original papers
Published online: 2004-01-01
Submitted: 2004-03-31
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The role of oxydative stress in the course of acute myeloblastic leukaemias

Dariusz Jawniak, Renata Jawniak, Magdalena Małek, Magdalena Górska
DOI: 10.1016/S1507-1367(04)71022-6
·
Rep Pract Oncol Radiother 2004;9(5):157-160.

open access

Vol 9, No 5 (2004)
Original papers
Published online: 2004-01-01
Submitted: 2004-03-31

Abstract

The aim of the study was to evaluate the influence of oxidative potential and activity of antioxidants on the course and chemotherapy response in acute nonlymphoblastic leukaemias.

Material and methods

Twelve adult patients (7 women, 5 men) with acute nonlymphoblastic leukaemia treated at the Department of Hematooncology University Medical School in Lublin, were studied. Plasma concentration of malondialdehyde (MDA) was determined using fluorimetric assay. Activities of superoxide dismutase (SOD) and glutathione peroxidase (PGx) were assesed in the whole blood using colorimetric assay with Randox reagents.

Results

The overall survival in the group of patients with a low activity of GPx (< 5.0 U/ml) was significantly longer than that in patients with a high activity of GPx (15.71±9.8 vs 5.8±3.68 month). Patients with hepatosplenomegaly were characterized by a significantly lower activity of SOD (52.0U/ml) compared to patients without hepatosplenomegaly (95.12 U/ml).

Conclusion

The state of the new balance between different defence mechanisms of an oxidation-reduction system, resulting from the presence of acute proliferation, may modulate the course of acute leukaemias and influence the response to chemotherapy.

Abstract

The aim of the study was to evaluate the influence of oxidative potential and activity of antioxidants on the course and chemotherapy response in acute nonlymphoblastic leukaemias.

Material and methods

Twelve adult patients (7 women, 5 men) with acute nonlymphoblastic leukaemia treated at the Department of Hematooncology University Medical School in Lublin, were studied. Plasma concentration of malondialdehyde (MDA) was determined using fluorimetric assay. Activities of superoxide dismutase (SOD) and glutathione peroxidase (PGx) were assesed in the whole blood using colorimetric assay with Randox reagents.

Results

The overall survival in the group of patients with a low activity of GPx (< 5.0 U/ml) was significantly longer than that in patients with a high activity of GPx (15.71±9.8 vs 5.8±3.68 month). Patients with hepatosplenomegaly were characterized by a significantly lower activity of SOD (52.0U/ml) compared to patients without hepatosplenomegaly (95.12 U/ml).

Conclusion

The state of the new balance between different defence mechanisms of an oxidation-reduction system, resulting from the presence of acute proliferation, may modulate the course of acute leukaemias and influence the response to chemotherapy.

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Keywords

oxidative stress; acute nonlymphoblastic leukemia; GPx; SOD; MDA

About this article
Title

The role of oxydative stress in the course of acute myeloblastic leukaemias

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 9, No 5 (2004)

Pages

157-160

Published online

2004-01-01

DOI

10.1016/S1507-1367(04)71022-6

Bibliographic record

Rep Pract Oncol Radiother 2004;9(5):157-160.

Keywords

oxidative stress
acute nonlymphoblastic leukemia
GPx
SOD
MDA

Authors

Dariusz Jawniak
Renata Jawniak
Magdalena Małek
Magdalena Górska

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