The preliminary evaluation of conformal hypofractionated radiotherapy (3D) toxicity in prostate cancer patients

Abstract

Purpose

The purpose of this retrospective study was to evaluate the degree of acute and late genitourinary (GU) and gastrointestinal (GI) toxicity of conformal hypofractionated radiotherapy (3DRTH) in prostate cancer patients.

Materials and methods

From January 1998 to July 2000, 137 (T1-T3NxM0) patients were treated with combine therapy: neoadjuvant hormonal therapy not less then 3 months and 3DRTH. The median follow-up was 20 (range 6–43) months. The degree of acute and late GI and GU toxicity was graded according RTOG/EORTC scale. A 3D technique was developed. We used 4 MV and 15 MV photon beams treating all fields (3 field –blocks or MLC) 5 days a week with 2.6 Gy per fraction to a total dose of 52 Gy to the prostate.

Results

Acute GU toxicity: lack −34(25%), I° −90(65%), II°- 12(9%), III° −1(1%). Late GU toxicity: lack – 128(94%), I° −6(4%), II°- 2(1.5%), III° −1(0.5%). Acute GI toxicity : lack – 77(56%), I°- 55(40%), II° −5(4%), III°- 0. Late GI toxicity: lack – 129(94%), I°- 8(6%), II° −0, III°-0.

Conclusions

The hyperfractionated radiotherapy schedule for localized prostate cancer seems to be a safe method of irradiation. Dose escalation should also be considered.