open access

Vol 8, No 2 (2003)
Original papers
Published online: 2003-01-01
Submitted: 2002-10-18
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Twice a day hypofractionated irradiation in patients with brain metastases. Final results of prospective non randomized study

Teresa Szpytma, Elżbieta Pluta, Jadwiga Nowak-Sadzikowska, Bogdan Gliński, Jan Skołyszewski
DOI: 10.1016/S1507-1367(03)70995-X
·
Rep Pract Oncol Radiother 2003;8(2):57-64.

open access

Vol 8, No 2 (2003)
Original papers
Published online: 2003-01-01
Submitted: 2002-10-18

Abstract

Aim

To evaluate the morbidity and effectivness of twice a day hypofractionation in patients with brain metastases.

Material / methods

Between 1992 and 2000, 116 patients with brain metastases have been treated with whole brain radiotherapy alone and only in 33 patients radiotherapy was applied as adjuvant treatment after surgery. Radiotherapy was given in two of 3 Gy fractions daily with minimum 6 hours intervals between fractions to total dose of 39 Gy. Mean age of treated patients was 55 years. All patients were in general performance status evaluated according to the Karnofsky Performance Scale of at least 50.

Results

Early tolerance of treatment was acceptable. Of 116 patients only 20 patients were treated with supportive treatment (anti-oedema drugs). Improvement of the neurological status was obtained in 26 patients (22%). The one-year overall survival was 21%. The one–year survival without clinical progression of disease was observed in 10% of all treated patients. Patients with solitary brain metastases treated with surgery and radiotherapy showed the best results.

Conclusions

Our results showed that twice a day hypo-fractionation radiotherapy for patients with brain metastases is well tolerated and may provides benefit.

Abstract

Aim

To evaluate the morbidity and effectivness of twice a day hypofractionation in patients with brain metastases.

Material / methods

Between 1992 and 2000, 116 patients with brain metastases have been treated with whole brain radiotherapy alone and only in 33 patients radiotherapy was applied as adjuvant treatment after surgery. Radiotherapy was given in two of 3 Gy fractions daily with minimum 6 hours intervals between fractions to total dose of 39 Gy. Mean age of treated patients was 55 years. All patients were in general performance status evaluated according to the Karnofsky Performance Scale of at least 50.

Results

Early tolerance of treatment was acceptable. Of 116 patients only 20 patients were treated with supportive treatment (anti-oedema drugs). Improvement of the neurological status was obtained in 26 patients (22%). The one-year overall survival was 21%. The one–year survival without clinical progression of disease was observed in 10% of all treated patients. Patients with solitary brain metastases treated with surgery and radiotherapy showed the best results.

Conclusions

Our results showed that twice a day hypo-fractionation radiotherapy for patients with brain metastases is well tolerated and may provides benefit.

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Keywords

brain metastases; radiotherapy; toxicity; hypofractionation

About this article
Title

Twice a day hypofractionated irradiation in patients with brain metastases. Final results of prospective non randomized study

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 8, No 2 (2003)

Pages

57-64

Published online

2003-01-01

DOI

10.1016/S1507-1367(03)70995-X

Bibliographic record

Rep Pract Oncol Radiother 2003;8(2):57-64.

Keywords

brain metastases
radiotherapy
toxicity
hypofractionation

Authors

Teresa Szpytma
Elżbieta Pluta
Jadwiga Nowak-Sadzikowska
Bogdan Gliński
Jan Skołyszewski

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