open access

Vol 7, No 2 (2002)
Published online: 2002-01-01
Submitted: 2001-05-10
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Radiobiological considerations of re-irradiation tolerance of the spinal cord

Sanjay S. Supe, K.M. Ganesh, J. Velmurugan, B.S. Rana, B.N. Sankar
DOI: 10.1016/S1507-1367(02)70982-6
·
Rep Pract Oncol Radiother 2002;7(2):81-85.

open access

Vol 7, No 2 (2002)
Published online: 2002-01-01
Submitted: 2001-05-10

Abstract

Re-irradiation tolerance of the spinal cord depends upon the volume of the spinal cord irradiated, the total dose, the dose per fractional, the elapsed time between the treatments and the region of the spinal cord involved. Clinical data on the retreatment tolerance of the spinal cord are sparse and inconclusive. Radiobiological laboratory evidence has indicated the presence of long term recovery of the spinal cord damage. Fractionation sensitivity during reirradiation is comparable with the first session of radiation treatment. After an initial dose of 45 Gy, 50% recovery has been reported by Schultheiss and Stephens for an elapsed period of two years for re-irradiation considerations.

Abstract

Re-irradiation tolerance of the spinal cord depends upon the volume of the spinal cord irradiated, the total dose, the dose per fractional, the elapsed time between the treatments and the region of the spinal cord involved. Clinical data on the retreatment tolerance of the spinal cord are sparse and inconclusive. Radiobiological laboratory evidence has indicated the presence of long term recovery of the spinal cord damage. Fractionation sensitivity during reirradiation is comparable with the first session of radiation treatment. After an initial dose of 45 Gy, 50% recovery has been reported by Schultheiss and Stephens for an elapsed period of two years for re-irradiation considerations.

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About this article
Title

Radiobiological considerations of re-irradiation tolerance of the spinal cord

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 7, No 2 (2002)

Pages

81-85

Published online

2002-01-01

DOI

10.1016/S1507-1367(02)70982-6

Bibliographic record

Rep Pract Oncol Radiother 2002;7(2):81-85.

Authors

Sanjay S. Supe
K.M. Ganesh
J. Velmurugan
B.S. Rana
B.N. Sankar

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