Results of postoperative radiotherapy in low-grade gliomas

Abstract

Purpose

To evaluate results of postoperative radiotherapy (PRT) for Low-Grade Gliomas (LGG).

Material/Methods

Between 1985 and 1995, 158 patients with LGG (WHO II) received PRT. A multivariate analysis for possible prognostic factors was performed. CT scans taken prior to surgery and at the time of recurrence were compared to define the recurrence pattern in relation to initial tumour site and the irradiated volume.

Results

Ten-year overall and progression free survival rates were 41% and 29%, respectively. A multivariate analysis revealed that good WHO performance status, seizures at presentation, duration of symptoms before treatment >12 months, age <45 years and gross total resection were associated with increased survival. All but three analysed recurrences occurred within the initial tumour sites. There was only one case of recurrence outside the previously irradiated volume.

Conclusions

Long-term treatment results were unfavourable for most LGG patients. Our data confirm the prognostic value of the above-mentioned factors.