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Results of postoperative radiotherapy in low-grade gliomas
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Abstract
Purpose
To evaluate results of postoperative radiotherapy (PRT) for Low-Grade Gliomas (LGG).
Material/Methods
Between 1985 and 1995, 158 patients with LGG (WHO II) received PRT. A multivariate analysis for possible prognostic factors was performed. CT scans taken prior to surgery and at the time of recurrence were compared to define the recurrence pattern in relation to initial tumour site and the irradiated volume.
Results
Ten-year overall and progression free survival rates were 41% and 29%, respectively. A multivariate analysis revealed that good WHO performance status, seizures at presentation, duration of symptoms before treatment >12 months, age <45 years and gross total resection were associated with increased survival. All but three analysed recurrences occurred within the initial tumour sites. There was only one case of recurrence outside the previously irradiated volume.
Conclusions
Long-term treatment results were unfavourable for most LGG patients. Our data confirm the prognostic value of the above-mentioned factors.
Abstract
Purpose
To evaluate results of postoperative radiotherapy (PRT) for Low-Grade Gliomas (LGG).
Material/Methods
Between 1985 and 1995, 158 patients with LGG (WHO II) received PRT. A multivariate analysis for possible prognostic factors was performed. CT scans taken prior to surgery and at the time of recurrence were compared to define the recurrence pattern in relation to initial tumour site and the irradiated volume.
Results
Ten-year overall and progression free survival rates were 41% and 29%, respectively. A multivariate analysis revealed that good WHO performance status, seizures at presentation, duration of symptoms before treatment >12 months, age <45 years and gross total resection were associated with increased survival. All but three analysed recurrences occurred within the initial tumour sites. There was only one case of recurrence outside the previously irradiated volume.
Conclusions
Long-term treatment results were unfavourable for most LGG patients. Our data confirm the prognostic value of the above-mentioned factors.
Keywords
Low-Grade Glioma; Postoperative Radiotherapy; Prognostic Factors; Pattern of failures
About this articleTitle
Results of postoperative radiotherapy in low-grade gliomas
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
61-73
Published online
2002-01-01
DOI
10.1016/S1507-1367(02)70980-2
Bibliographic record
Rep Pract Oncol Radiother 2002;7(2):61-73.
Keywords
Low-Grade Glioma
Postoperative Radiotherapy
Prognostic Factors
Pattern of failures
Authors
Lucyna Kępka
Jacek Fijuth
Czesława Leszczyk
Katarzyna Dyttus-Cebulok
Agnieszka Zolciak