open access

Vol 26, No 1 (2021)
Research paper
Published online: 2021-01-22
Submitted: 2021-01-08
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Preliminary clinical outcomes of patients treated with vaginal brachytherapy alone using multi-channel vaginal brachytherapy applicator in operated early-stage endometrial cancer

Karthik S. Rishi, Savitha David, Muddappa Pathikonda, Prakash Ramachandra, Giri G.V., Annapurna Vadaparty, Srinath B.S.
DOI: 10.5603/RPOR.a2021.0007
·
Rep Pract Oncol Radiother 2021;26(1):43-49.

open access

Vol 26, No 1 (2021)
Original research articles
Published online: 2021-01-22
Submitted: 2021-01-08

Abstract

Background: Recommendations for adjuvant treatment for postoperative, early-stage endometrial cancer varies from observation through vaginal brachytherapy alone to pelvic radiation. While observation alone can lead to recurrence, external radiotherapy has increased morbidity. The aim of this study is to show our results with vaginal brachytherapy alone using a multichannel applicator for treatment of early-stage endometrial cancer.

Materials and methods: Consecutive patients undergoing vaginal brachytherapy alone following surgery for early-stage endometrial cancer were examined. A Miami multichannel vaginal brachytherapy applicator was used to deliver HDR brachytherapy in 62 patients from May 2013 to June 2018. CT scan-based images guided planning. A dose of 5.5–6.5 Gy × 4 fractions was prescribed 5 mm from the surface of the applicator.

Results: At a median follow up of 19 months (6–48 months), 93% of patients treated were alive with no recurrence. Two patients had only local recurrence, and 1 was salvaged with external radiotherapy and chemotherapy. There was only one nodal failure and 2 distant failures. There was no grade 2 or higher vaginal, gastrointestinal or genitourinary toxicity.

Conclusion: Vaginal brachytherapy alone using a multichannel applicator can be considered for early-stage endometrial cancers without compromising outcomes.

Abstract

Background: Recommendations for adjuvant treatment for postoperative, early-stage endometrial cancer varies from observation through vaginal brachytherapy alone to pelvic radiation. While observation alone can lead to recurrence, external radiotherapy has increased morbidity. The aim of this study is to show our results with vaginal brachytherapy alone using a multichannel applicator for treatment of early-stage endometrial cancer.

Materials and methods: Consecutive patients undergoing vaginal brachytherapy alone following surgery for early-stage endometrial cancer were examined. A Miami multichannel vaginal brachytherapy applicator was used to deliver HDR brachytherapy in 62 patients from May 2013 to June 2018. CT scan-based images guided planning. A dose of 5.5–6.5 Gy × 4 fractions was prescribed 5 mm from the surface of the applicator.

Results: At a median follow up of 19 months (6–48 months), 93% of patients treated were alive with no recurrence. Two patients had only local recurrence, and 1 was salvaged with external radiotherapy and chemotherapy. There was only one nodal failure and 2 distant failures. There was no grade 2 or higher vaginal, gastrointestinal or genitourinary toxicity.

Conclusion: Vaginal brachytherapy alone using a multichannel applicator can be considered for early-stage endometrial cancers without compromising outcomes.

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Keywords

endometrium; brachytherapy; multichannel brachytherapy applicator

About this article
Title

Preliminary clinical outcomes of patients treated with vaginal brachytherapy alone using multi-channel vaginal brachytherapy applicator in operated early-stage endometrial cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 26, No 1 (2021)

Article type

Research paper

Pages

43-49

Published online

2021-01-22

DOI

10.5603/RPOR.a2021.0007

Bibliographic record

Rep Pract Oncol Radiother 2021;26(1):43-49.

Keywords

endometrium
brachytherapy
multichannel brachytherapy applicator

Authors

Karthik S. Rishi
Savitha David
Muddappa Pathikonda
Prakash Ramachandra
Giri G.V.
Annapurna Vadaparty
Srinath B.S.

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