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Difficulties in the diagnosis of antisynthetase syndrome
, 1
Affiliations- Department of Rheumatology, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, Poland
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Abstract
Antisynthetase syndrome is a rare subtype of idiopathic inflammatory myopathies, characterised by co-ocurrence of myositis, arthritis, interstitial lung disease, Raynaud phenomenon, fever and mechanic’s hands. Symptoms frequently appear asynchronously. The presence of antisynthetase antibodies in a patient’s serum is considered an immunological hallmark of the disease. Arriving at a proper diagnosis of antisynthetase syndrome remains a considerable challenge, and the diagnosis is often delayed. The manuscript discusses possible obstacles in the diagnostic process of antisynthetase syndrome.
Abstract
Antisynthetase syndrome is a rare subtype of idiopathic inflammatory myopathies, characterised by co-ocurrence of myositis, arthritis, interstitial lung disease, Raynaud phenomenon, fever and mechanic’s hands. Symptoms frequently appear asynchronously. The presence of antisynthetase antibodies in a patient’s serum is considered an immunological hallmark of the disease. Arriving at a proper diagnosis of antisynthetase syndrome remains a considerable challenge, and the diagnosis is often delayed. The manuscript discusses possible obstacles in the diagnostic process of antisynthetase syndrome.
Keywords
antisyntetase syndrome; idiopathic inflammatory myopathies; interstitial lung disease; arthritis; diagnosis
About this articleTitle
Difficulties in the diagnosis of antisynthetase syndrome
Journal
Issue
Article type
Review paper
Pages
84-90
Published online
2022-06-23
Page views
4467
Article views/downloads
1221
DOI
Bibliographic record
Rheumatology Forum 2022;8(2):84-90.
Keywords
antisyntetase syndrome
idiopathic inflammatory myopathies
interstitial lung disease
arthritis
diagnosis
Authors
Aleksandra Opinc
Joanna Makowska
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