Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Rheumatology Forum
MENU
Shortcuts Submit an article Author Guidelines Ahead Of Print Editorial Team

open access

Vol 7, No 1 (2021)
Review paper
Published online: 2021-05-20
View PDF (Polish) Download PDF file
Get Citation

Mechanizm, działanie i skuteczność glikokortykosteroidów w polimialgii reumatycznej i olbrzymiokomórkowym zapaleniu tętnic –– czy te leki są zawsze skuteczne?

Bogna Grygiel-Górniak1, Agnieszka Szczepańska2, Marta Lubarska2, Włodzimierz Samborski1
DOI: 10.5603/FR.2021.0006
·
Forum Reumatol 2021;7(1):27-34.
Affiliations
  1. Katedra i Klinika Reumatologii, Rehabilitacji i Chorób Wewnętrznych, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Fredry 10, 61-701 Poznań
  2. Rheumatology Research Group, Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im W. Degi, ul. 28 Czerwca 1956 r. 135/147, 61-545 Poznań, Poland

open access

Vol 7, No 1 (2021)
Review
Published online: 2021-05-20

Abstract

W terapii polimialgii reumatycznej (PMR, polymialgia rheumatica) i olbrzymiokomórkowego zapalenia tętnic (GCA, giant cells arthritis) lekami pierwszego wyboru są glikokortykosteroidy (GKS). Powyższe choroby wymagają często wieloletniego leczenia, dlatego należy zwrócić szczególną uwagę na szerokie spektrum działań niepożądanych tych leków. Problemem, z którym można spotkać się w praktyce klinicznej, jest steroidooporność. W niniejszej publikacji zebrano najnowsze doniesienia naukowe dotyczących skuteczności terapii GKS w PMR współistniejącej (lub nie) z GCA.

Abstract

W terapii polimialgii reumatycznej (PMR, polymialgia rheumatica) i olbrzymiokomórkowego zapalenia tętnic (GCA, giant cells arthritis) lekami pierwszego wyboru są glikokortykosteroidy (GKS). Powyższe choroby wymagają często wieloletniego leczenia, dlatego należy zwrócić szczególną uwagę na szerokie spektrum działań niepożądanych tych leków. Problemem, z którym można spotkać się w praktyce klinicznej, jest steroidooporność. W niniejszej publikacji zebrano najnowsze doniesienia naukowe dotyczących skuteczności terapii GKS w PMR współistniejącej (lub nie) z GCA.

Full Text:

View PDF (Polish) Download PDF file
Get Citation

Keywords

polimialgia reumatyczna; olbrzymiokomórkowe zapalenie tętnic; steroidoterapia

About this article
Title

Mechanizm, działanie i skuteczność glikokortykosteroidów w polimialgii reumatycznej i olbrzymiokomórkowym zapaleniu tętnic –– czy te leki są zawsze skuteczne?

Journal

Rheumatology Forum

Issue

Vol 7, No 1 (2021)

Article type

Review paper

Pages

27-34

Published online

2021-05-20

Page views

2852

Article views/downloads

578

DOI

10.5603/FR.2021.0006

Bibliographic record

Forum Reumatol 2021;7(1):27-34.

Keywords

polimialgia reumatyczna
olbrzymiokomórkowe zapalenie tętnic
steroidoterapia

Authors

Bogna Grygiel-Górniak
Agnieszka Szczepańska
Marta Lubarska
Włodzimierz Samborski

References (46)
  1. Fors C, Bergström U, Willim M, Pilman E, Turesson C. Validity of polymyalgia rheumatica diagnoses and classification criteria in primary health care. Rheumatol Adv Pract. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799851/ (23 styczenia 2021).
  2. Hunder GG. Classification/diagnostic criteria for GCA/PMR. Clin Exp Rheumatol. 2000; 18(4 Suppl 20): S4–S5.
    PubMed
  3. Cantini F, Niccoli L, Storri L, et al. Are polymyalgia rheumatica and giant cell arteritis the same disease? Semin Arthritis Rheum. 2004; 33(5): 294–301.
    CrossRefPubMed
  4. Albrecht K, Huscher D, Buttgereit F, et al. Long-term glucocorticoid treatment in patients with polymyalgia rheumatica, giant cell arteritis, or both diseases: results from a national rheumatology database. Rheumatol Int. 2018; 38(4): 569–577.
    CrossRefPubMed
  5. Yin Y, Zhang Y, Wang D, et al. Differences in clinical manifestations and prognosis of Chinese giant cell arteritis patients with or without polymyalgia rheumatica. Ir J Med Sci. 2019; 188(2): 713–720.
    CrossRefPubMed
  6. Kermani TA. Polymyalgia rheumatica. 2013; 381: 10.
  7. Raczkiewicz A. Starszy pacjent w standardach postępowania reumatologicznego. Forum Medycyny Rodzinnej. 2009; 5(3): 372–379.
  8. Pyszel A, Andrzejak R, Szuba A. Large-vessel giant cell arteritis. 2006; 12(1): 8.
  9. Adizie T, Dasgupta B. PMR and GCA: steroids or bust. International Journal of Clinical Practice. 2012; 66(6): 524–527.
    CrossRef
  10. Kermani TA, Sreih AG, Cuthbertson D, et al. Vasculitis Clinical Research Consortium. Evaluation of damage in giant cell arteritis. Rheumatology (Oxford). 2018; 57(2): 322–328.
    CrossRefPubMed
  11. Grzanka A, Misiołek M, Golusiński W, et al. [Nongenomic effects of glucocorticoids]. Pneumonol Alergol Pol. 2009; 77(4): 387–393.
    PubMed
  12. Becker DE. Basic and clinical pharmacology of glucocorticosteroids. Anesth Prog. 2013; 60(1): 25–31; quiz 32.
    CrossRefPubMed
  13. Martinez-Taboada VM, Alvarez L, RuizSoto M, et al. Giant cell arteritis and polymyalgia rheumatica: role of cytokines in the pathogenesis and implications for treatment. Cytokine. 2008; 44(2): 207–220.
    CrossRefPubMed
  14. Spies CM, Bijlsma JWJ, Burmester GR, et al. Pharmacology of glucocorticoids in rheumatoid arthritis. Curr Opin Pharmacol. 2010; 10(3): 302–307.
    CrossRefPubMed
  15. Stahn C, Buttgereit F. Genomic and nongenomic effects of glucocorticoids. Nat Clin Pract Rheumatol. 2008; 4(10): 525–533.
    CrossRefPubMed
  16. Schäcke H, Schottelius A, Döcke WD, et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc Natl Acad Sci U S A. 2004; 101(1): 227–232.
    CrossRefPubMed
  17. Hübner S, Dejager L, Libert C, et al. The glucocorticoid receptor in inflammatory processes: transrepression is not enough. Biol Chem. 2015; 396(11): 1223–1231.
    CrossRefPubMed
  18. Hayashi R, Wada H, Ito K, et al. Effects of glucocorticoids on gene transcription. Eur J Pharmacol. 2004; 500(1-3): 51–62.
    CrossRefPubMed
  19. Buttgereit F, Scheffold A. Rapid glucocorticoid effects on immune cells. Steroids. 2002; 67(6): 529–534.
    CrossRef
  20. Song IH, Buttgereit F. Non-genomic glucocorticoid effects to provide the basis for new drug developments. Mol Cell Endocrinol. 2006; 246(1-2): 142–146.
    CrossRefPubMed
  21. Buttgereit F, Brand MD, Burmester GR. Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy. Biochem Pharmacol. 1999; 58(2): 363–368.
    CrossRefPubMed
  22. Stellato C. Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc. 2004; 1(3): 255–263.
    CrossRefPubMed
  23. Haller J, Mikics E, Makara GB. The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings. Front Neuroendocrinol. 2008; 29(2): 273–291.
    CrossRefPubMed
  24. Malcher-Lopes R, Di S, Marcheselli VS, et al. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci. 2006; 26(24): 6643–6650.
    CrossRefPubMed
  25. Mackiewicz S. Review paper
    Glucocorticoid therapy – success or illusion. Reumatologia/Rheumatology. 2007; 45(4): 198–204.
  26. Oray M, Abu Samra K, Ebrahimiadib N, et al. Long-term side effects of glucocorticoids. Expert Opin Drug Saf. 2016; 15(4): 457–465.
    CrossRefPubMed
  27. Cheah JTL, Robson JC, Black RJ, et al. The patient's perspective of the adverse effects of glucocorticoid use: A systematic review of quantitative and qualitative studies. From an OMERACT working group. Semin Arthritis Rheum. 2020; 50(5): 996–1005.
    CrossRefPubMed
  28. Pereira R, Carvalho JF. Glucocorticoid-induced myopathy. Joint Bone Spine. 2011; 78(1): 41–44.
    CrossRef
  29. Sato A, Funder JW, Okubo M, et al. Glucocorticoid-induced hypertension in the elderly. Relation to serum calcium and family history of essential hypertension. Am J Hypertens. 1995; 8(8): 823–828.
    CrossRefPubMed
  30. Mori S, Koga Y. Glucocorticoid-resistant polymyalgia rheumatica: pretreatment characteristics and tocilizumab therapy. Clin Rheumatol. 2016; 35(5): 1367–1375.
    CrossRefPubMed
  31. Lally L, Spiera R. Management of difficult polymyalgia rheumatica and giant cell arteritis: Updates for clinical practice. Best Pract Res Clin Rheumatol. 2018; 32(6): 803–812.
    CrossRefPubMed
  32. Liozon E, Dumonteil S, Parreau S, et al. Risk profiling for a refractory course of giant cell arteritis: The importance of age and body weight: "Risk profiling for GC resistance in GCA". Semin Arthritis Rheum. 2020; 50(6): 1252–1261.
    CrossRefPubMed
  33. Weyand CM, Goronzy JJ. Immune mechanisms in medium and large-vessel vasculitis. Nat Rev Rheumatol. 2013; 9(12): 731–740.
    CrossRefPubMed
  34. van der Geest KSM, Abdulahad WH, Rutgers A, et al. Serum markers associated with disease activity in giant cell arteritis and polymyalgia rheumatica. Rheumatology (Oxford). 2015; 54(8): 1397–1402.
    CrossRefPubMed
  35. Owen CE, McMaster C, Liew DFL, et al. Neutrophil to lymphocyte ratio predicts glucocorticoid resistance in polymyalgia rheumatica. Int J Rheum Dis. 2021; 24(1): 56–62.
    CrossRefPubMed
  36. Jung JY, Lee E, Suh CH, et al. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are associated with disease activity in polymyalgia rheumatica. J Clin Lab Anal. 2019; 33(9): e23000.
    CrossRefPubMed
  37. Templeton AJ, McNamara MG, Šeruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014; 106(6): dju124.
    CrossRefPubMed
  38. Kötter I, Henes JC, Wagner AD, et al. Does glucocorticosteroid-resistant large-vessel vasculitis (giant cell arteritis and Takayasu arteritis) exist and how can remission be achieved? A critical review of the literature. Clin Exp Rheumatol. 2012; 30(1 Suppl 70): S114–S129.
    PubMed
  39. Cimmino MA, Parodi M, Montecucco C, et al. The correct prednisone starting dose in polymyalgia rheumatica is related to body weight but not to disease severity. BMC Musculoskelet Disord. 2011; 12(1): 94.
    CrossRefPubMed
  40. Ponte C, Rodrigues AF, O'Neill L, et al. Giant cell arteritis: Current treatment and management. World J Clin Cases. 2015; 3(6): 484–494.
    CrossRefPubMed
  41. 2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative | Annals of the Rheumatic Diseases. https://ard.bmj.com/content/74/10/1799?etoc (13 stycznia 2021).
  42. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis | Annals of the Rheumatic Diseases. https://ard.bmj.com/content/79/1/19 (13 stycznia 2021).
  43. Mahr AD, Jover JA, Spiera RF, et al. Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis. Arthritis Rheum. 2007; 56(8): 2789–2797.
    CrossRefPubMed
  44. van der Veen MJ, Dinant HJ, van Booma-Frankfort C, et al. Can methotrexate be used as a steroid sparing agent in the treatment of polymyalgia rheumatica and giant cell arteritis? Ann Rheum Dis. 1996; 55(4): 218–223.
    CrossRefPubMed
  45. Camellino D, Soldano S, Cutolo M, et al. Dissecting the inflammatory response in polymyalgia rheumatica: the relative role of IL-6 and its inhibition. Rheumatol Int. 2018; 38(9): 1699–1704.
    CrossRefPubMed
  46. Braun N, Fritz P, Rieth A, et al. Predictors for treatment success and expression of glucocorticoid receptor in giant cell arteritis and polymyalgia rheumatica. J Rheumatol. 2009; 36(10): 2269–2276.
    CrossRefPubMed

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl