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Use of mycophenolate mofetil in refractory relapsing polychondritis
, 1, 1, 1, 12
Affiliations- Department of Rheumatology and Immunology, Andrzej Frycz-Modrzewski Kraków University, Kraków, Poland
- Department of Rheumatology and Immunology, J. Dietl Hospital, Kraków, Poland
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Abstract
Relapsing polychondritis (RP) remains a difficult-to-treat disease of unknown aetiology and uncertain prognosis. Based on McAdam's criteria, rheumatoid arthritis (RA) was diagnosed in a 51-year-old female patient, and sequential therapy with dapsone — followed by naproxen and methylprednisolone — was initiated without achieving full remission. During the following years, the patient developed new locations of polychondritis (nose, epiphyses of long bones) and episcleritis. Methotrexate (MTX) was started, which was changed to mycophenolate mofetil (MM) due to adverse effects, resulting in sustained clinical improvement. There were no relapses during the subsequent 12 months of follow-up. The use of MM with good therapeutic effect in our patient is one of the few reported cases of such therapy in a patient with RP.
Abstract
Relapsing polychondritis (RP) remains a difficult-to-treat disease of unknown aetiology and uncertain prognosis. Based on McAdam's criteria, rheumatoid arthritis (RA) was diagnosed in a 51-year-old female patient, and sequential therapy with dapsone — followed by naproxen and methylprednisolone — was initiated without achieving full remission. During the following years, the patient developed new locations of polychondritis (nose, epiphyses of long bones) and episcleritis. Methotrexate (MTX) was started, which was changed to mycophenolate mofetil (MM) due to adverse effects, resulting in sustained clinical improvement. There were no relapses during the subsequent 12 months of follow-up. The use of MM with good therapeutic effect in our patient is one of the few reported cases of such therapy in a patient with RP.
Keywords
relapsing polychondritis; mycophenolate mofetil; humoral response; cellular response; biologics
About this articleTitle
Use of mycophenolate mofetil in refractory relapsing polychondritis
Journal
Issue
Article type
Case report
Pages
43-47
Published online
2024-01-24
Page views
144
Article views/downloads
40
DOI
Bibliographic record
Rheumatology Forum 2024;10(1):43-47.
Keywords
relapsing polychondritis
mycophenolate mofetil
humoral response
cellular response
biologics
Authors
Przemyslaw Borowy
Jakub Smyk
Patrycja Major
Natalia Mglej
Bogdan Batko
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