Vol 8, No 2 (2022)
Review paper
Published online: 2022-06-23

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Difficulties in the diagnosis of antisynthetase syndrome

Aleksandra Opinc1, Joanna Makowska1
Rheumatology Forum 2022;8(2):84-90.


Antisynthetase syndrome is a rare subtype of idiopathic inflammatory myopathies, characterised by co-ocurrence of myositis, arthritis, interstitial lung disease, Raynaud phenomenon, fever and mechanic’s hands. Symptoms frequently appear asynchronously. The presence of antisynthetase antibodies in a patient’s serum is considered an immunological hallmark of the disease. Arriving at a proper diagnosis of antisynthetase syndrome remains a considerable challenge, and the diagnosis is often delayed. The manuscript discusses possible obstacles in the diagnostic process of antisynthetase syndrome.

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