Vol 4, No 2 (2018)
Review paper
Published online: 2018-06-20
Budowa i funkcja ludzkich antygenów zgodności tkankowej. Część 2. Funkcja antygenów zgodności tkankowej
Forum Reumatol 2018;4(2):87-94.
Abstract
Antygeny zgodności tkankowej odgrywają kluczową rolę w regulacji aktywności układu immunologicznego. Prezentacja antygenów egzogennych (pochodzących z białek wewnątrzkomórkowych) w kontekście klasycznych MHC klasy II pomocniczym limfocytom T umożliwia indukcję odpowiedzi immunologicznej. Rozpoznanie przez cytotoksyczne limfocyty T prezentowanych przez klasyczne MHC klasy I endogennych peptydów pochodzących z wewnątrzkomórkowych patogenów skutkuje zabiciem zakażonej komórki. Wysoki polimorfizm antygenów HLA zapewnia rozpoznanie szerokiego repertuaru peptydów, a więc także różnego rodzaju czynników infekcyjnych, co warunkuje skuteczną eliminację patogenu z ustroju.
Forum Reumatol. 2018, tom 4, nr 2: 87–94
Keywords: wiązanie peptydów przez cząsteczki MHCmechanizm prezentacji antygenubiologiczne znaczenie polimorfizmu MHC
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