ANCA antibodies in ulcerative colitis with coexisting extraintestinal symptoms
Abstract
ANCA associated vasculitis are a group of connective tissue diseases characterized by a very variable course and clinical presentation. Diagnosis is difficult and complications can lead to disabilities or even death. Standard management often requires long-term immunosuppressive therapy and corticosteroids. ANCA antibodies can be considered as an important biomarker in the diagnosis of this group of vasculitis. However, it is important to remember that there are other diseases where ANCA antibodies can be detected. Ulcerative colitis is one of these diseases and its extra-intestinal symptoms can imitate vasculitis. Presented case report shows diagnostic and therapeutic difficulties occurring in this set of patients.
Keywords: ANCA antibodiesvasculitisgranulomatosis with polyangiitisulcerative colitisinflammatory bowel diseases
References
- Houben E, Bax WA, van Dam B, et al. Diagnosing ANCA-associated vasculitis in ANCA positive patients: A retrospective analysis on the role of clinical symptoms and the ANCA titre. Medicine (Baltimore). 2016; 95(40): e5096.
- Wiatr E, Gawryluk D. Pierwotne systemowe zapalenia naczyń związane z przeciwciałami przeciwcytoplazmatycznymi (ANCA) — rekomendacje diagnostyczne i lecznicze. Pneumonol Alergol Pol. 2013; 81: 479–491.
- Jennette JC, Jennette JC, Falk RJ, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013; 65(1): 1–11.
- Kyriakidi KS, Tsianos VE, Karvounis E, et al. Neutrophil anti-neutrophil cytoplasmic autoantibody proteins: bactericidal increasing protein, lactoferrin, cathepsin, and elastase as serological markers of inflammatory bowel and other diseases. Ann Gastroenterol. 2016; 29(3): 258–267.
- Söderberg D, Segelmark M. Neutrophil Extracellular Traps in ANCA-Associated Vasculitis. Front Immunol. 2016; 7: 256.
- Tang S, Zhang Y, Yin SW, et al. Neutrophil extracellular trap formation is associated with autophagy-related signalling in ANCA-associated vasculitis. Clin Exp Immunol. 2015; 180(3): 408–418.
- Schulte-Pelkum J, Radice A, Norman GL, et al. Novel clinical and diagnostic aspects of antineutrophil cytoplasmic antibodies. J Immunol Res. 2014; 2014: 185416.
- Fischer K, Brzosko I, Brzosko M. Autoprzeciwciała w praktyce reumatologicznej. Forum Reumatol. 2016; 1(2): 39–50.
- Szczeklik A, Sznajd J. Zapalenia naczyń. In: Szczeklik A. ed. Interna Szczeklika. Medycyna Praktyczna, Kraków 2014: 1877–1894.
- Yates M, Watts RA, Bajema IM, et al. Bajema I. M. EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis Ann Rheum Dis 2016;75. ; 9: 1583–1594.
- Marchioni Beery R, Kane S. Current approaches to the management of new-onset ulcerative colitis. Clin Exp Gastroenterol. 2014; 7: 111–132.
- Bürger M, Schmidt C, Teich N, et al. Medical Therapy of Active Ulcerative Colitis. Viszeralmedizin. 2015; 31(4): 236–245.
- Vutcovici M, Brassard P, Bitton A, et al. Increased incidence of inflammatory bowel disease in Québec residents with airway diseases. Eur Respir J. 2015; 45(4): 962–968.
- Leavitt RY, Fauci AS, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of vasculitis. Patients and methods. Arthritis Rheum. 1990; 33(8): 1068–1073.
- Masi AT, Hunder GG, Lie JT, et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum. 1990; 33(8): 1094–1100.
- Draibe JB, Fulladosa X, Cruzado JM, et al. Current and novel biomarkers in anti-neutrophil cytoplasm-associated vasculitis. Clin Kidney J. 2016; 9(4): 547–551.
