Vol 3, No 1 (2017)
Review paper
Published online: 2017-04-19

open access

Page views 726
Article views/downloads 911
Get Citation

Connect on Social Media

Connect on Social Media

The use of radiosynovectomy in the rheumatologic practice

Katarzyna Jodłowska-Cicio, Dorota Telesińska-Jasiówka, Aneta Bielińska, Mariusz Korkosz
Forum Reumatol 2017;3(1):18-23.

Abstract

Radiosynovectomy is a noninvasive method of local treatment of the joint synovitis using radioisotope. The radiation emitted by the radioisotope placed in the joint, causes fibrosis of the inflamed synovium and then its restoration and the return of its physi­ological properties. This method is widely used in rheumatology, bringing benefits to patients with rheumatoid arthritis, psoriatic arthritis, haemophilic arthropathy, pigmented villonodular synovitis and other diseases. The relatively uncomplicated tech­nique of injection of the radioisotope into the joint, the rare occurrence of side effects and a good response to the treatment make this method an alternative to surgical and chemical synovectomy as well as an useful addition to the pharmacologic treatment.

Article available in PDF format

View PDF (Polish) Download PDF file

References

  1. Fellinger K, Schmid J. Local therapy of rheumatic diseases. Wien Z Inn Med. 1952; 33(9): 351–363.
  2. Liepe K. Efficacy of radiosynovectomy in rheumatoid arthritis. Rheumatology International. 2011; 32(10): 3219–3224.
  3. Knut L. Radiosynovectomy in the therapeutic management of arthritis. World J Nucl Med. 2015; 14(1): 10–15.
  4. Das Bk. Role of radiosynovectomy in the treatment of rheumatoid arthritis and hemophilic arthropathies. Biomed Imaging Interv J. 2007; 3(4): e45.
  5. Schneider P, Farahati J, Reiners C. Radiosynovectomy in Rheumatology. 2015; 46(1): 48–55.
  6. Purpose IE. Procedure Guidelines for Radiosynovectomy. Eur J Nucl Med. 2003; 30(3).
  7. Zdrowia M. Dziennik urzędowy. 2015; 1–781. [A: niejasny zapis]
  8. Fischer M, Mödder G. Radionuclide therapy of inflammatory joint diseases. Nucl Med Commun. 2002; 23(9): 829–831.
  9. Matryba M, Wisłowska M. Zastosowanie scyntygrafii w reumatologii. Reumatologia. 2009; 47(5): 290–299.
  10. Zuderman L, Liepe K, Zöphel K, et al. Radiosynoviorthesis (RSO): influencing factors and therapy monitoring. Ann Nucl Med. 2008; 22(9): 735–741.
  11. Karavida N, Notopoulos A. Radiation Synovectomy: an effective alternative treatment for inflamed small joints. Hippokratia. 2010; 14(1): 22–27.
  12. Matryba M, Wisłowska M. Zastosowanie radiosynowektomii w leczeniu chorób reumatycznych. Reumatologia. 2010; 48: 54–61.
  13. Vuorela J, Sokka T, Pukkala E, et al. Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis? Ann Rheum Dis. 2003; 62(3): 251–253.
  14. Klett R, Puille M, Matter HP, et al. [Activity leakage and radiation exposure in radiation synovectomy of the knee: influence of different therapeutic modalities]. Z Rheumatol. 1999; 58(4): 207–212.
  15. Kampen W. Local Complications After Radiosynovectomy and Possible Treatment Strategies: A Literature Survey. Local Treatment of Inflammatory Joint Diseases. 2015: 115–125.
  16. Kampen WU, Matis E, Czech N, et al. Serious complications after radiosynoviorthesis. Survey on frequency and treatment modalities. Nuklearmedizin. 2006; 45(6): 262–268.
  17. Kisielinski K, Bremer D, Knutsen A, et al. Complications following radiosynoviorthesis in osteoarthritis and arthroplasty: osteonecrosis and intra-articular infection. Joint Bone Spine. 2010; 77(3): 252–257.
  18. Markou P, Chatzopoulos D. Yttrium-90 silicate radiosynovectomy treatment of painful synovitis in knee osteoarthritis. Results after 6 months. Hell J Nucl Med. 2009; 12(1): 33–36.
  19. Wong Y, Cherk MH, Powell A, et al. Efficacy of yttrium-90 synovectomy across a spectrum of arthropathies in an era of improved disease modifying drugs and treatment protocols. Int J Rheum Dis. 2014; 17(1): 78–83.
  20. Shabat S, Kollender Y, Merimsky O, et al. The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints. Rheumatology (Oxford). 2002; 41(10): 1113–1118.
  21. Bielińska A, Korkosz M, Gąsowski J, et al. Yttrium-90 distribution following radiosynoviorthesis of the knee joint in rheumatoid arthritis patients: a SPECT/CT study. Ann Nucl Med. 2014; 28(7): 688–692.