Online first
Review paper
Published online: 2024-08-13
The pathogenic relationship between metabolic syndrome and rheumatoid arthritis activity
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Abstract
Metabolic syndrome (MetS) and its components often occur in patients with rheumatoid arthritis (RA). Both conditions, RA and MetS, share pro-inflammatory pathogenic mechanisms. The occurrence of MetS in patients with RA seems to be associated with higher disease activity and suboptimal response to treatment. In this review, we have presented the pathogenesis of MetS and its associations with metabolic disorders in RA. Screening for and managing MetS is necessary to reduce cardiovascular risk and improve prognosis in patients with RA.
Keywords: rheumatoid arthritismetabolic syndromedisease activity
References
- Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010; 69(9): 1580–1588.
- Ferraz-Amaro I, González-Juanatey C, López-Mejias R, et al. Metabolic syndrome in rheumatoid arthritis. Mediators Inflamm. 2013; 2013: 710928.
- Behl T, Kaur I, Sehgal A, et al. The Lipid Paradox as a Metabolic Checkpoint and Its Therapeutic Significance in Ameliorating the Associated Cardiovascular Risks in Rheumatoid Arthritis Patients. Int J Mol Sci. 2020; 21(24).
- Luo P, Xu W, Ye D, et al. Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis: A Prospective Cohort Study Including 369,065 Participants. J Rheumatol. 2024; 51(4): 360–367.
- Alberti KG, Eckel RH, Grundy SM, et al. International Diabetes Federation Task Force on Epidemiology and Prevention, Hational Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120(16): 1640–1645.
- Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006; 23(5): 469–480.
- Pacholczyk M, Ferenc T, Kowalski J. [The metabolic syndrome. Part II: its mechanisms of development and its complications]. Postepy Hig Med Dosw (Online). 2008; 62: 543–558.
- Góralska M, Majewska-Szczepanik M, Szczepanik M. [Immunological mechanisms involved in obesity and their role in metabolic syndrome]. Postepy Hig Med Dosw (Online). 2015; 69: 1384–1404.
- Santos-Moreno P, Rodríguez-Vargas GS, Martínez S, et al. Metabolic Abnormalities, Cardiovascular Disease, and Metabolic Syndrome in Adult Rheumatoid Arthritis Patients: Current Perspectives and Clinical Implications. Open Access Rheumatol. 2022; 14: 255–267.
- Hallajzadeh J, Safiri S, Mansournia MA, et al. Metabolic syndrome and its components among rheumatoid arthritis patients: A comprehensive updated systematic review and meta-analysis. PLoS One. 2017; 12(3): e0170361.
- Santo RCE, Fernandes KZ, Lora PS, et al. Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2018; 9(5): 816–825.
- Targońska-Stępniak B, Majdan M. Associations between parameters of nutritional status and disease activity in patients with rheumatoid arthritis. Pol Arch Med Wewn. 2011; 121(4): 122–128.
- Małecka-Massalska T, Majdan A. Malnutrition and obesity among patients with rheumatoid arthritis and chronic inflammatory process. Wiad Lek. 2018; 72(1): 52–58.
- Elkan AC, Håkansson N, Frostegård J, et al. Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther. 2009; 11(2): R37.
- Poudel D, George MD, Baker JF. The Impact of Obesity on Disease Activity and Treatment Response in Rheumatoid Arthritis. Curr Rheumatol Rep. 2020; 22(9): 56.
- Stavropoulos-Kalinoglou A, Metsios GS, Koutedakis Y, et al. Redefining overweight and obesity in rheumatoid arthritis patients. Ann Rheum Dis. 2007; 66(10): 1316–1321.
- Minamino H, Katsushima M, Yoshida T, et al. Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database. PLoS One. 2020; 15(3): e0229998.
- Targońska-Stepniak B, Dryglewska M, Majdan M. Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol Int. 2010; 30(6): 731–737.
- Moroni L, Farina N, Dagna L. Obesity and its role in the management of rheumatoid and psoriatic arthritis. Clin Rheumatol. 2020; 39(4): 1039–1047.
- Bhattacharya PK, Barman B, Jamil Md, et al. Metabolic Syndrome and Atherogenic Indices in Rheumatoid Arthritis and their Relationship with Disease Activity: A Hospital-based Study from Northeast India. J Transl Int Med. 2020; 8(2): 99–105.
- Pandey PK, Swami A, Biswas TK, et al. Prevalence of Metabolic Syndrome in Treatment Naïve Rheumatoid Arthritis and Correlation With Disease Parameters. Arch Rheumatol. 2017; 32(1): 46–52.
- Dao HH, Do QT, Sakamoto J. Increased frequency of metabolic syndrome among Vietnamese women with early rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther. 2010; 12(6): R218.
- Gomes KW, Luz AJ, Felipe MR, et al. Prevalence of metabolic syndrome in rheumatoid arthritis patients from Northeastern Brazil: Association with disease activity. Mod Rheumatol. 2018; 28(2): 258–263.
- Gaafar A, Aly M, Amer A. Metabolic syndrome, hematological markers of inflammation and disease activity in rheumatoid arthritis. Int J Clin Rheumatol. 2021; 16(2): 052–058.
- Eldin A, ElBakry S, Morad C, et al. The impact of metabolic syndrome on rheumatoid arthritis in a cohort of Egyptian patients. Egypt Rheumatol. 2018; 40(1): 7–10.
- Burli AP, Dave M. Clinical & Demographic Profile and Prevalence of Metabolic Syndrome Among Patients with Rheumatoid Arthritis and its Correlation with Disease Activity. J Assoc Physicians India. 2022; 70(4): 11–12.
- Karvounaris SA, Sidiropoulos PI, Papadakis JA, et al. Metabolic syndrome is common among middle-to-older aged Mediterranean patients with rheumatoid arthritis and correlates with disease activity: a retrospective, cross-sectional, controlled, study. Ann Rheum Dis. 2007; 66(1): 28–33.
- Azevedo S, Santos-Faria D, Leite Silva J, et al. Obesity, metabolic syndrome and other comorbidities in rheumatoid arthritis and psoriatic arthritis: influence on disease activity and quality of life. Acta Reumatol Port. 2019; 44(4): 322–324.
- Kononoff A, Vuolteenaho K, Hämäläinen M, et al. Metabolic Syndrome, Disease Activity, and Adipokines in Patients With Newly Diagnosed Inflammatory Joint Diseases. J Clin Rheumatol. 2021; 27(8): e349–e356.
- Grzechnik K, Targońska-Stępniak B. Metabolic Syndrome and Rheumatoid Arthritis Activity: An Analysis of Clinical, Laboratory, and Ultrasound Parameters. Nutrients. 2023; 15(22).
