Cryoglobulinaemic vasculitis secondary to mantle cell lymphoma presenting with necrosis of fingers
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Abstract
We report a case of a male patient with mantle cell lymphoma (MCL) with secondary cryoglobulinaemic vasculitis without monoclonal protein. MCL was diagnosed during the diagnostics of necrosis of fingers, the first symptom of the underlying disease. The diagnosis was made after excluding other causes of cryoglobulinaemia, including infectious and autoimmune causes. The progression of necrosis was inhibited after the initiation of MCL treatment (rituximab, glucocorticoids) and symptomatic treatment (vasodilators).
This article describes the first MCL case associated with extensive necrosis of the fingers. Cryoglobulinaemic vasculitis without monoclonal protein due to malignancy is rare. An oncological aetiology must also be considered during the differential diagnosis of the causes of vasculitis, even if cancer symptoms are absent.
Keywords: cryoglobulinaemic vasculitiscryoglobuilinaemianecrosismantle cell lymphoma
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