Renal dysfunction in patients with liver cirrhosis

Abstract

Kidney dysfunction, both acute kidney injury (AKI) and chronic kidney disease (CKD) is a relatively common and significant problem in cirrhosis and occursin approximately 20–25% of patients. These may complicate primary disorders of the liver and are primarily related to disturbances in circulatory function, and an abnormal systemic and renal neuro-humoral regulation. The coexisted liver and kidney disease can occur as a result of systemic process that affects both organs simultaneously. Renal dysfunctionin patients with cirrhosis is associated with significant morbidity and mortality. The prognostic impact of renal function is reflected by incorporation of serum creatinine in the model for end-stage liver disease score (MELD). Moreover, pretransplant renal functionis important factor and correlates with posttransplant outcomes. Renal impairment is difficult to recognize in the early stages. Assessment of renal function in cirrhotic patients is crucial. Clinicians indicate, there is a need for newer classification of renal dysfunction, uniform standards for defining AKI and searching for alternative markers and methods of assessing kidney function. Earlier identification of risk patients may allow intervention to prevent or appropriate treat renal dysfunction in these patients.