Hepatitis C virus and kidney transplantation
, 1
Abstract
Kidney transplantation is the treatment of choice in
patients with end-stage kidney disease. Hepatitis C
virus infection in kidney transplant recipients is associated
with numerous complications. Apart from
hepatitis and consecutive cirrhosis, patients with
HCV infections are more prone to develop severe
infections, post-transplant diabetes mellitus, and
recurrence of HCV-induced glomerulonephritis in
transplanted kidneys. Patients after kidney transplantation
with HCV infection are at higher risk of
death. Previously used treatment based on interferon
and ribavirin was poorly tolerated by this group and
had low efficacy. Introducing direct-acting antivirals
(DAA) was a breakthrough for patients with kidney
disease, including kidney transplant recipients. DAA
treatment rarely has side effects and prevents many
complications associated with HCV infection.
Keywords: hepatitis Ckidney transplantation
References
- Fabrizi F, Martin P, Dixit V, et al. Hepatitis C virus antibody status and survival after renal transplantation: meta-analysis of observational studies. Am J Transplant. 2005; 5(6): 1452–1461.
- Dalrymple LS, Koepsell T, Sampson J, et al. Hepatitis C virus infection and the prevalence of renal insufficiency. Clin J Am Soc Nephrol. 2007; 2(4): 715–721.
- Tomasiewicz K, Flisiak R, Jaroszewicz J, et al. Recommendations of the Polish Group of Experts for HCV for the treatment of hepatitis C in 2023. Clin Exp Hepatol. 2023; 9(1): 1–8.
- Sikorska-Wiśniewska M, Sikorska K, Wróblewska A, et al. Recurrence of Cryoglobulinemia Secondary to Hepatitis C in a Patient with HCV RNA (-) Negative in the Serum. Case Rep Nephrol Dial. 2021; 11(2): 110–115.
- Guide to the quality and safety of organs for transplantation, 8th edition. www.edqm.eu.
- Zylberberg H, Nalpas B, Carnot F, et al. Severe evolution of chronic hepatitis C in renal transplantation: a case control study. Nephrol Dial Transplant. 2002; 17(1): 129–133.
- Morales JM, Pascual-Capdevila J, Campistol JM, et al. Membranous glomerulonephritis associated with hepatitis C virus infection in renal transplant patients. Transplantation. 1997; 63(11): 1634–1639.
- Mahmoud IM, Elhabashi AF, Elsawy E, et al. The impact of hepatitis C virus viremia on renal graft and patient survival: a 9-year prospective study. Am J Kidney Dis. 2004; 43(1): 131–139.
- Martin P, Awan AA, Berenguer MC, et al. Executive Summary of the KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease. Kidney Int. 2022; 102(6): 1228–1237.
- Mitwalli AH, Alam A, Al-Wakeel J, et al. Effect of chronic viral hepatitis on graft survival in Saudi renal transplant patients. Nephron Clin Pract. 2006; 102(2): c72–c80.
- Periera BJ, Wright TL, Schmid CH, et al. The impact of pretransplantation hepatitis C infection on the outcome of renal transplantation. Transplantation. 1995; 60(8): 799–805.
- Corell A, Morales JM, Mandroño A, et al. Immunosuppression induced by hepatitis C virus infection reduces acute renal-transplant rejection. Lancet. 1995; 346(8988): 1497–1498.
- Hanish SI, Samaniego M, Mezrich JD, et al. Outcomes of simultaneous liver/kidney transplants are equivalent to kidney transplant alone: a preliminary report. Transplantation. 2010; 90(1): 52–60.
- Sangiovanni A, Prati GM, Fasani P, et al. The natural history of compensated cirrhosis due to hepatitis C virus: A 17-year cohort study of 214 patients. Hepatology. 2006; 26(6): 1303–1310.
- Waziry R, Hajarizadeh B, Grebely J, et al. Hepatocellular carcinoma risk following direct-acting antiviral HCV therapy: A systematic review, meta-analyses, and meta-regression. J Hepatol. 2017; 67(6): 1204–1212.
- Pereira BJ, Milford EL, Kirkman RL, et al. Transmission of hepatitis C virus by organ transplantation. N Engl J Med. 1991; 325(7): 454–460.
- Sawinski D, Forde KA, Lo Re V, et al. Mortality and Kidney Transplantation Outcomes Among Hepatitis C Virus-Seropositive Maintenance Dialysis Patients: A Retrospective Cohort Study. Am J Kidney Dis. 2019; 73(6): 815–826.
