dostęp płatny
Tom 19, Nr 2 (2022)
Artykuł przeglądowy
Opublikowany online: 2021-12-30
Pobierz cytowanie
Use of verapamil as a P-glycoprotein inhibitor in patients with drug-resistant depression
1
Afiliacje- Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, ul. Pyskowicka 49, 42-612 Tarnowskie Góry, Polska
dostęp płatny
Tom 19, Nr 2 (2022)
Artykuły przeglądowe
Opublikowany online: 2021-12-30
Streszczenie
Drug-resistant depression is a common occurrence in clinical practice. Current antidepressant therapies have a high
failure rate. A P-glycoprotein as a blood-brain barrier component could limit the distribution of these drugs into the
brain. Verapamil is the most extensively characterized P-gp inhibitor and probably verapamil prevents up-regulation
of P-gp expression. Co-administration of P-gp inhibitors with P-gp-substarate drugs (antidepressants) represents
a potential strategy to overcome drug resistance.
Streszczenie
Drug-resistant depression is a common occurrence in clinical practice. Current antidepressant therapies have a high
failure rate. A P-glycoprotein as a blood-brain barrier component could limit the distribution of these drugs into the
brain. Verapamil is the most extensively characterized P-gp inhibitor and probably verapamil prevents up-regulation
of P-gp expression. Co-administration of P-gp inhibitors with P-gp-substarate drugs (antidepressants) represents
a potential strategy to overcome drug resistance.
Pełny tekst:
Dodaj do koszyka: 49,00 PLN
Pobierz cytowanie
Słowa kluczowe
verapamil, drug-resistant depression
Informacje o artykuleTytuł
Use of verapamil as a P-glycoprotein inhibitor in patients with drug-resistant depression
Czasopismo
Numer
Typ artykułu
Artykuł przeglądowy
Strony
144-153
Opublikowany online
2021-12-30
Wyświetlenia strony
3952
Wyświetlenia/pobrania artykułu
13
DOI
Rekord bibliograficzny
Psychiatria 2022;19(2):144-153.
Słowa kluczowe
verapamil
drug-resistant depression
Autorzy
Jarosław Sobiś
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